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Vol. 17, No. 4, 2004
Issue release date: June 2004
Section title: Paper
Dement Geriatr Cogn Disord 2004;17:355–359
(DOI:10.1159/000077171)

Frontotemporal Dementia: A Randomised, Controlled Trial with Trazodone

Lebert F. · Stekke W. · Hasenbroekx C. · Pasquier F.
aMemory Clinic, Lille University Hospital, Lille, France; bPharmacia Laboratory, Diegem, cDepartment of Neurology, Heilig Hart Ziekenhuis, Roeselare, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/10/2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Behavioural troubles due to frontotemporal dementia (FTD) are difficult to treat. The serotonergic system is associated with frontal lobes, the degeneration of which contributes to FTD. Trazodone increases the extracellular 5-HT levels in the frontal cortex. In a randomised, double-blind, placebo-controlled cross-over study, we investigated the effect of trazodone. There was a significant decrease in the Neuropsychiatry Inventory (NPI) total score with trazodone (p = 0.028) in the 26 evaluable patients. A decrease of more than 50% in the NPI score was observed in 10 patients with trazodone. This improvement was mainly based on the improvement of 4 items of the scale (irritability, agitation, depressive symptoms and eating disorders). The Mini-Mental State Examination was not modified and trazodone was well tolerated. Results of this first placebo-controlled trial suggest that trazodone is an effective treatment for the behavioural symptoms of FTD.


  

Author Contacts

Dr. Florence Lebert
Centre de la Mémoire, Hôpital Roger Salengro
Centre Hospitalier Universitaire
FR–59037 Lille (France)
Tel. +33 3 20 44 60 21, Fax +33 3 28 43 47 46, E-Mail flebert@nordnet.fr

  

Article Information

Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 2, Number of References : 14

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 17, No. 4, Year 2004 (Cover Date: Released June 2004)

Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/journals/dem


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/10/2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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