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Vol. 9, No. 3, 2004
Issue release date: May–June 2004
Section title: Original Paper
Audiol Neurootol 2004;9:135–143
(DOI:10.1159/000077264)

Adenovirus-Mediated Expression of Brain-Derived Neurotrophic Factor Protects Spiral Ganglion Neurons from Ototoxic Damage

Nakaizumi T. · Kawamoto K. · Minoda R. · Raphael Y.
KHRI, University of Michigan, Ann Arbor, Mich., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/23/2003
Accepted: 11/7/2003
Published online: 4/15/2004

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD

Abstract

Hair cell loss, the most common cause of deafness, is often associated with auditory nerve degeneration. Our goal was to determine the influence of combined ciliary-derived neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) gene therapy on the survival of spiral ganglion neurons (SGNs) after elimination of inner hair cells in the mature guinea pig ear. Seven days after bilateral deafening, a 5-µl suspension of CNTF and/or BDNF adenovirus vectors was injected into the left scala tympani through the round window. Animals were sacrificed 28 days after deafening, and their inner ears were prepared for SGN counts. The SGN counts revealed that BDNF alone and the combined CNTF and BDNF treatment significantly enhanced SGN survival. CNTF did not significantly enhance the protective effect of BDNF. These data present possible strategies for enhancing SGN survival in cochlear implant procedures.


  

Author Contacts

Yehoash Raphael
University of Michigan, Department of Otolaryngology
MSRB III, Rm. 9303, 1150 W. Medical Center Dr.
Ann Arbor, MI 48109-0648 (USA)
Tel. +1 734 936 9386, Fax +1 734 647 2563, E-Mail yoash@umich.edu

  

Article Information

Received: July 23, 2003
Accepted after revision: November 7, 2003
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 0, Number of References : 84

  

Publication Details

Audiology & Neuro-Otology (Basic Research and Clinical Applications)

Vol. 9, No. 3, Year 2004 (Cover Date: May-June 2004)

Journal Editor: Manfried Hoke, Münster, Germany
ISSN: 1420–3030 (print), 1421–9700 (Online)

For additional information: http://www.karger.com/aud


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/23/2003
Accepted: 11/7/2003
Published online: 4/15/2004

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 0

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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