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Table of Contents
Vol. 79, No. 3, 2004
Issue release date: March 2004
Section title: Neuroendocrine Correlates of Obesity
Neuroendocrinology 2004;79:157–162
(DOI:10.1159/000077274)

Obesity and Plasma Concentrations of Alpha-Tocopherol and Beta-Carotene in Epileptic Girls Treated with Valproate

Verrotti A.a · Greco R.a · Latini G.b · De Simone M.c · Chiarelli F.a
aDepartment of Medicine, Section of Pediatrics, University of Chieti, Chieti; bDepartment of Pediatrics, Hospital of Brindisi, Brindisi, and cDepartment of Pediatrics, University of L’Aquila, L’Aquila, Italy

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Article / Publication Details

First-Page Preview
Abstract of Neuroendocrine Correlates of Obesity

Received: August 08, 2003
Accepted: February 17, 2004
Published online: January 14, 2005
Issue release date: March 2004

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

To investigate whether epileptic patients who become obese after valproic acid (VPA) therapy can have a high risk of atherosclerosis related to the oxidation of low-density lipoprotein, we prospectively studied the plasma concentrations of lipid-soluble antioxidant vitamins in a group of 20 epileptic girls and 20 controls. After 1 year of VPA treatment, epileptic patients who gained weight had decreased plasma concentrations of α-tocopherol and α- and β-carotene, the main lipid-soluble antioxidants. Moreover, 5 patients who gained weight were reevaluated 6 months after withdrawal from VPA therapy and showed normal body mass indices and normalized plasma levels of antioxidants. In conclusion, the data suggest that epileptic patients who gain weight after VPA therapy have reduced plasma concentrations of antioxidant vitamins and that these reductions are reversible after VPA withdrawal.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Neuroendocrine Correlates of Obesity

Received: August 08, 2003
Accepted: February 17, 2004
Published online: January 14, 2005
Issue release date: March 2004

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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