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Vol. 79, No. 3, 2004
Issue release date: March 2004
Section title: Neuroendocrine Correlates of Obesity
Neuroendocrinology 2004;79:157–162
(DOI:10.1159/000077274)

Obesity and Plasma Concentrations of Alpha-Tocopherol and Beta-Carotene in Epileptic Girls Treated with Valproate

Verrotti A. · Greco R. · Latini G. · De Simone M. · Chiarelli F.
aDepartment of Medicine, Section of Pediatrics, University of Chieti, Chieti; bDepartment of Pediatrics, Hospital of Brindisi, Brindisi, and cDepartment of Pediatrics, University of L’Aquila, L’Aquila, Italy

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Article / Publication Details

First-Page Preview
Abstract of Neuroendocrine Correlates of Obesity

Received: 8/8/2003
Accepted: 2/17/2004
Published online: 1/14/2005

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

To investigate whether epileptic patients who become obese after valproic acid (VPA) therapy can have a high risk of atherosclerosis related to the oxidation of low-density lipoprotein, we prospectively studied the plasma concentrations of lipid-soluble antioxidant vitamins in a group of 20 epileptic girls and 20 controls. After 1 year of VPA treatment, epileptic patients who gained weight had decreased plasma concentrations of α-tocopherol and α- and β-carotene, the main lipid-soluble antioxidants. Moreover, 5 patients who gained weight were reevaluated 6 months after withdrawal from VPA therapy and showed normal body mass indices and normalized plasma levels of antioxidants. In conclusion, the data suggest that epileptic patients who gain weight after VPA therapy have reduced plasma concentrations of antioxidant vitamins and that these reductions are reversible after VPA withdrawal.


  

Author Contacts

Alberto Verrotti
Department of Pediatrics, University of Chieti
Ospedale Policlinico, Via dei Vestini 5
IT–66013 Chieti (Italy)
Tel. +39 0871 358015/574538, Fax +39 0871 574831, E-Mail averrott@obelix.unich.it

  

Article Information

Received: August 8, 2003
Accepted after revision: February 17, 2004
Published online: April 16, 2004
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 2, Number of References : 26

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)
Founded 1965 by E. Bajusz. Continued by K.M. Knigge (1973–1978), W.F. Ganong (1979–1984), S.M. McCann (1985–1993)

Vol. 79, No. 3, Year 2004 (Cover Date: March 2004)

Journal Editor: C. Kordon, Paris
ISSN: 0028–3835 (print), 1423–0194 (Online)

For additional information: http://www.karger.com/journals/nen


Article / Publication Details

First-Page Preview
Abstract of Neuroendocrine Correlates of Obesity

Received: 8/8/2003
Accepted: 2/17/2004
Published online: 1/14/2005

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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