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Table of Contents
Vol. 49, No. 4, 2004
Issue release date: May 2004
Section title: Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper
Neuropsychobiology 2004;49:196–200
(DOI:10.1159/000077366)

Association Study of a Functional Catechol-O-Methyltransferase Genetic Polymorphism with Age of Onset, Cognitive Function, Symptomatology and Prognosis in Chronic Schizophrenia

Tsai S.-J.a,b · Hong C.-J.a,b · Liao D.-L.c · Lai I.-C.d · Liou Y.-J.d
aDepartment of Psychiatry, Taipei Veterans General Hospital, bDivision of Psychiatry, School of Medicine, National Yang-Ming University, cDepartment of Psychiatry, Executive Yuan Department of Health, Pali Psychiatric Hospital, Taipei, and dSection of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, ROC

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Published online: May 06, 2004
Issue release date: May 2004

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. This study aimed to assess the relationship between a functional polymorphism (Val158Met) of the COMT gene and age of onset (AOO), symptomatology, global cognitive function and prognosis in patients with schizophrenia. The study enrolled 154 patients with schizophrenia from chronic wards. Results failed to show a significant association between the Val158Met polymorphism and the Brief Psychiatric Rating Scale scores, Mini-Mental State Examination scores, and Social and Occupational Functioning Assessment Scale scores, but COMT Val158Met heterozygotes had a later AOO than homozygous patients. However, by further expanding the number of patients to 228 patients, the differences in AOO among the three COMT genotypic groups was not significant. The COMT Val158Met polymorphism did not appear to significantly affect susceptibility, symptomatology, global cognitive function and prognosis in Chinese patients with schizophrenia, but the possible association with AOO merits further investigation.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels). Original Paper

Published online: May 06, 2004
Issue release date: May 2004

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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