Region-Specific Decline of Cerebral Glucose Metabolism in Patients with Frontotemporal Dementia: A Prospective 18F-FDG-PET StudyGrimmer T. · Diehl J. · Drzezga A. · Förstl H. · Kurz A.
Departments of aPsychiatry and Psychotherapy, bNuclear Medicine, Technical University Munich, Munich, Germany
Objective: The aim of this study was to examine the pattern of glucose uptake and the changes over time of metabolic deficits in patients with frontotemporal dementia (FTD). Methods: 10 patients who had received the clinical diagnosis of FTD underwent positron emission tomography scanning at the time of their first examination (baseline) and at follow-up (after 17.1 ± 6.0 months). For statistical analysis, we used the SPM 99 software. First, we compared the data of the patients at baseline with an age-matched healthy control group. Second, we compared glucose uptake at follow-up with baseline measurements. Results: Compared with normal controls, FTD patients showed significant metabolic deficits primarily in frontal cortical areas, but also in the caudate nuclei and the thalami. At follow-up, a significant progression of metabolic deficit was exclusively observed in the orbitofrontal parts of the frontal lobe and in the subcortical structures. Discussion: These findings demonstrate that the clinical progression in patients with FTD is accompanied by a region-specific decline in cerebral glucose metabolism.
Klinik für Psychiatrie und Psychotherapie der Technischen Universität München
DE–81675 München (Germany)
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Accepted: September 23, 2003
Published online: April 6, 2004
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 0, Number of References : 26
Dementia and Geriatric Cognitive Disorders
Vol. 18, No. 1, Year 2004 (Cover Date: Released June 2004)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem