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Table of Contents
Vol. 18, No. 1, 2004
Issue release date: June 2004
Section title: Original Research Article
Dement Geriatr Cogn Disord 2004;18:50–54
(DOI:10.1159/000077735)

Effects of Cholinergic Drugs and Cognitive Training on Dementia

Requena C.a · López Ibor M.I.b · Maestú F.c · Campo P.c · López Ibor J.J.b · Ortiz T.b
aUniversidad de León (Área de Psicología), León, bDepartamento de Psiquiatría, Facultad de Medicina, and cCentro de Magnetoencefalografía, Universidad Complutense de Madrid, Madrid, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: October 06, 2003
Published online: June 17, 2004
Issue release date: June 2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

A study was performed on patients with Alzheimer’s disease (AD) in order to evaluate the efficacy of a combined treatment (donepezil plus cognitive training) in both cognitive processes and affective states. Eighty-six subjects, 25 men and 61 women, with an average age of 75.58 years, were studied. Almost all the subjects had a basic educational level. Donezepil was administered at a dose of 10 mg daily along with cognitive treatment involving images of everyday life and reminiscent music; the sessions took place on Monday to Friday and lasted three quarters of an hour. The study lasted 12 months. Subjects underwent test-retest with the following tests: Mini-Mental State Examination (MMSE), the cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-cog); the Geriatric Depression Scale (GDS) and the overall deterioration scale (FAST). The results showed that subjects receiving the combined treatment had a better response than those who did not receive any cognitive training. These subjects’ MMSE score decreased by 3.24 on average. The affective symptomatology of those receiving only drug treatment improved whereas the cognitive processes did not.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: October 06, 2003
Published online: June 17, 2004
Issue release date: June 2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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