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Vol. 50, No. 1, 2004
Issue release date: June 2004
Section title: Pharmacopsychiatry. Editor: B. Saletu (Vienna). Original Paper
Neuropsychobiology 2004;50:71–77
(DOI:10.1159/000077944)

Pharmacodynamic Effects of Acamprosate on Markers of Cerebral Function in Alcohol-Dependent Subjects Administered as Pretreatment and during Alcohol Abstinence

Boeijinga P.H. · Parot P. · Soufflet L. · Landron F. · Danel T. · Gendre I. · Muzet M. · Demazières A. · Luthringer R.
aFORENAP ‘Research Institute for Neuroscience, Pharmacology and Psychiatry’, Rouffach, bConseil en Pharmacologie Clinique, Massy, cMERCK Santé, Lyon, and dCHRU, Unité de psychopathologie et alcoologie clinique de l’anxiété, Lille, France

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Article / Publication Details

First-Page Preview
Abstract of Pharmacopsychiatry. Editor: B. Saletu (Vienna). Original Paper

Published online: 6/11/2004

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Animal studies suggested that acamprosate modulates neuronal hyperexcitability of acute alcohol withdrawal, acting through the glutamatergic neurotransmission. In the present study, we further investigated whether treatment with acamprosate could attenuate the post-alcohol withdrawal hyperexcitability or hyperarousal in humans using brain magnetoencephalography mapping of spontaneous fields. A double-blind, randomised, placebo-controlled study with a parallel group design comparing 2,000 mg/day of acamprosate versus placebo was conducted in alcohol-dependent subjects meeting DSM-IV criteria for alcohol dependence. Treatments were initiated 8 days before alcohol withdrawal and prolonged during the 15 following (abstinence) days. The study demonstrated that during alcohol withdrawal, acamprosate decreased the arousal level as reflected by alpha slow-wave index (ASI) measurement. This effect was mostly evidenced in left parietotemporal regions and, to a lesser extent, in the contiguous anterior, posterior and right-sided regions. In the placebo group, on the contrary, ASI measures increased between day 2 (acute withdrawal) and day 14 (prolonged withdrawal). The present results suggest a sustained effect of acamprosate on the hyperexcitability state due to alcohol withdrawal in alcohol-dependent patients and that acamprosate may have a protective effect when administered 8 days before alcohol withdrawal.


  

Author Contacts

P.H. Boeijinga
FORENAP Research Institute For Neuroscience, Pharmacology and Psychiatry
27, rue du 4ème RSM, FR–68250 Rouffach (France)
Tel. +33 3 89 76 71 26, Fax +33 3 89 78 51 24
E-Mail peter.boeijinga@forenap.asso.fr

  

Article Information

Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 39

  

Publication Details

Neuropsychobiology
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)

Vol. 50, No. 1, Year 2004 (Cover Date: Released June 2004)

Journal Editor: P. Netter, Giessen; J. Mendlewicz, Brussels; B. Saletu, Vienna
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/nps


Article / Publication Details

First-Page Preview
Abstract of Pharmacopsychiatry. Editor: B. Saletu (Vienna). Original Paper

Published online: 6/11/2004

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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