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Table of Contents
Vol. 14, No. 3, 2004
Issue release date: April 2004
Section title: Original Paper
Cell Physiol Biochem 2004;14:135–142
(DOI:10.1159/000078105)

Association of the Serum and Glucocorticoid Regulated Kinase (sgk1) Gene with QT Interval

Busjahn A.1,2 · Seebohm G.3 · Maier G.3 · Toliat M.R.4 · Nürnberg P.4 · Aydin A.1 · Luft F.C.1 · Lang F.3
1Franz Volhard Clinic, HELIOS Kliniken-Berlin and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, 2HealthTwiSt GmbH, Berlin, 3Department of Physiology, University of Tübingen, 4Gene Mapping Center (GMC), Max-Delbrück-Centrum, Berlin

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 30, 2004
Issue release date: April 2004

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: http://www.karger.com/CPB

Abstract

The serum and glucocorticoid inducible kinase (SGK1) is well known to up-regulate the renal epithelial Na+ channel ENaC. Excessive SGK1 activity would be expected to cause renal Na+ retention and blood pressure increase. Certain polymorphisms of the SGK1 gene (E8CC/CT;I6CC) are indeed associated with moderately enhanced blood pressure. We have recently disclosed another function of SGK1, i.e. the stimulation of the slowly activating K+ channel KCNE1/KCNQ1. Among the functions of this channel is the repolarisation of cardiac myocytes. Accordingly, defective KCNE1 and/or KCNQ1 lead to long QT syndrome, a disorder causing fainting and sudden cardiac death. In the present study we demonstrate that coexpression of SGK1 in Xenopus oocytes increases KCNQ1/KCNE1 induced current without significantly altering voltage dependence, activation and deactivation kinetics. To test for the relevance of SGK1 in human cardiac repolarization, we analysed the ECG of monozygotic (MZ) (126 pairs) and dizygotic (DZ) (70 pairs) twin subjects and parents of DZ twins. The E8CC/CT;I6CC polymorphism was indeed significantly (p<0.025) associated with shortened age and gender corrected QT interval. No significant differences were observed in any other ECG parameter, including heart rate, P, PQ and QRS. We conclude that the regulation of KCNE1/KCNQ1 by SGK1 is similarly relevant for the repolarization of cardiac myocytes as for regulation of renal ENaC activity and blood pressure control.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: April 30, 2004
Issue release date: April 2004

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: http://www.karger.com/CPB


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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