New mouse genetic models for human contraceptive developmentLessard C. · Pendola J.K. · Hartford S.A. · Schimenti J.C. · Handel M.A. · Eppig J.J.
The Jackson Laboratory, Bar Harbor, ME (USA)
Genetic strategies for the post-genomic sequence age will be designed to provide information about gene function in a myriad of physiological processes. Here an ENU mutagenesis program (http://reprogenomics.jax.org) is described that is generating a large resource of mutant mouse models of infertility; male and female mutants with defects in a wide range of reproductive processes are being recovered. Identification of the genes responsible for these defects, and the pathways in which these genes function, will advance the fields of reproduction research and medicine. Importantly, this program has potential to reveal novel human contraceptive targets.
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C.L. and J.K.P. contributed equally to this paper.
Supported by a grant from the NIH (HD42137) to J.J.E, M.A.H. and J.C.S.
Received 8 October 2003;
manuscript accepted 19 November 2003.
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 0, Number of References : 37
Cytogenetic and Genome Research
Formerly ‘Cytogenetics and Cell Genetics’
Vol. 105, No. 2-4, Year 2004 (Cover Date: 2004)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 1424–8581 (print), 1424–859X (Online)
For additional information: http://www.karger.com/journals/cgr