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Vol. 134, No. 1, 2004
Issue release date: May 2004
Section title: Review
Int Arch Allergy Immunol 2004;134:65–78
(DOI:10.1159/000078339)

The Role of Tec Family Kinases in Myeloid Cells

Schmidt U. · Boucheron N. · Unger B. · Ellmeier W.
aMedical University of Vienna, Institute of Immunology and bBMT-Vienna, Vienna, Austria

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 3/30/2004
Published online: 5/28/2004

Number of Print Pages: 14
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Members of the Tec kinase family (Bmx, Btk, Itk, Rlk and Tec) are primarily expressed in the hematopoietic system and form, after the Src kinase family, the second largest class of non-receptor protein tyrosine kinases. During lymphocyte development and activation Tec kinases have important functions in signaling pathways downstream of the antigen receptors. Tec family kinases are also expressed in cells of the myeloid lineage. However, with the exception of mast cells and platelets, their biological role in the myeloid system is only poorly understood. This review summarizes the current knowledge about the function of Tec family kinases in hematopoietic cells of the myeloid lineage.


  

Author Contacts

Correspondence to: Dr. Wilfried Ellmeier
Institute of Immunology, Medical University of Vienna
Brunner Strasse 59
AT–1235 Vienna (Austria)
Tel. +43 1 4277 64986, Fax +43 1 4277 64991, E-Mail wilfried.ellmeier@univie.ac.at

  

Article Information

Published online: May 4, 2004
Number of Print Pages : 14
Number of Figures : 3, Number of Tables : 1, Number of References : 117

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950
Official Journal of the Collegium Internationale Allergologicum

Vol. 134, No. 1, Year 2004 (Cover Date: May 2004)

Journal Editor: R. Valenta, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 3/30/2004
Published online: 5/28/2004

Number of Print Pages: 14
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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