Members of the Tec kinase family (Bmx, Btk, Itk, Rlk and Tec) are primarily expressed in the hematopoietic system and form, after the Src kinase family, the second largest class of non-receptor protein tyrosine kinases. During lymphocyte development and activation Tec kinases have important functions in signaling pathways downstream of the antigen receptors. Tec family kinases are also expressed in cells of the myeloid lineage. However, with the exception of mast cells and platelets, their biological role in the myeloid system is only poorly understood. This review summarizes the current knowledge about the function of Tec family kinases in hematopoietic cells of the myeloid lineage.
© 2004 S. Karger AG, Basel
Correspondence to: Dr. Wilfried Ellmeier
Institute of Immunology, Medical University of Vienna
Brunner Strasse 59
AT–1235 Vienna (Austria)
Tel. +43 1 4277 64986, Fax +43 1 4277 64991, E-Mail firstname.lastname@example.org
Published online: May 4, 2004
Number of Print Pages : 14
Number of Figures : 3, Number of Tables : 1, Number of References : 117
International Archives of Allergy and Immunology
Official Journal of the Collegium Internationale Allergologicum
Vol. 134, No. 1, Year 2004 (Cover Date: May 2004)
Journal Editor: R. Valenta, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)
For additional information:http://www.karger.com/iaa
Article / Publication Details
Published online: 5/28/2004
Issue release date: May 2004
Number of Print Pages: 14
Number of Figures: 3
Number of Tables: 1
ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA
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