Family History and Risk of Hair LossChumlea W.C. · Rhodes T. · Girman C.J. · Johnson-Levonas A. · Lilly F.R.W. · Wu R. · Guo S.S.
aDepartment of Community Health, Wright State University School of Medicine, Dayton, Ohio, bDepartment of Epidemiology, Merck Research Laboratories, West Point, Pa., cDepartment of Endocrinology and Metabolism, Merck Research Laboratories, Rahway, N.J., and dDepartment of Community Planning, Hanover Hospital, Hanover, Pa., USA
Introduction: The genetic basis of androgenetic alopecia (AGA) is well accepted in the medical community and among the general population. However, rigorous studies investigating the familial basis of AGA are lacking. The purpose of the current study was to explore the relationship between family history and expression of AGA in a sample of men from the general community. Methods: Hair loss was assessed by an independent observer trained by an expert dermatologist using the Norwood/Hamilton classification scale and a 7-point global description of hair loss. Men were classified into two groups, one as having little or no hair loss and the other having hair loss. The family history of hair loss in parents and grandparents was assessed by subject self-report. Results: Adjusting for age, men whose fathers had hair loss were 2.5 times as likely to have had some level of hair loss compared to men whose fathers had no hair loss (95% CI: 1.3–4.9). Likewise, men whose fathers had hair loss were twice as likely to have hair loss than men whose fathers had no hair loss even after adjusting for age (OR = 2.1, 95% CI: 1.2–3.7 and OR = 2.5, 95% CI: 1.4–4.7 for Norwood/Hamilton and global description of hair loss assessments, respectively). Conclusion: Results suggest that the probability of male pattern hair loss is dependent on family history and age. Hair loss in a man’s father also appears to play an important role in increasing a man’s risk of hair loss, either in conjunction with a history of hair loss in the mother or hair loss in the maternal grandfather.
Merck Research Laboratories, Department of Epidemiology
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Received: July 7, 2003
Accepted: February 14, 2004
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 5, Number of References : 22
Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology
Vol. 209, No. 1, Year 2004 (Cover Date: 2004)
Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)
For additional information: http://www.karger.com/journals/drm