Journal Mobile Options
Table of Contents
Vol. 72, No. 1, 2004
Issue release date: August 2004
Section title: Short Communication
Pharmacology 2004;72:1–5
(DOI:10.1159/000078625)

Efficacy of Donepezil Treatment in Alzheimer Patients with and without Subcortical Vascular Lesions

Blasko I. · Bodner T. · Knaus G. · Walch T. · Monsch A. · Hinterhuber H. · Marksteiner J.
aDepartment of Psychiatry, University Hospital of Innsbruck, Innsbruck, Austria, and bGeriatric University Hospital, Basel, Switzerland

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 1/27/2004
Accepted: 3/23/2004
Published online: 8/6/2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

In a pilot study designed as a case control study the efficacy of donepezil treatment was investigated in patients with Alzheimer’s disease (AD). Patients were stratified according to radiological criteria into patients without (AD group) and with subcortical vascular lesions (AD+SVD group). Changes in cognition were assessed as the primary outcome measurement after 6 and 18 months of treatment by the Mini-Mental Status Examination (MMSE) and the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) test battery. After 6 months, patients had improved from baseline by 0.7 points in MMSE score in the AD group and by 1.8 in the AD+SVD group. After 18 months of treatment, the AD+SVD group performed significantly worse in one CERAD subscore, whereas a deterioration in two subscores was observed in the AD group. A comparison between the 2 groups revealed that treatment did not lead to statistically significant differences between the AD and AD+SVD groups in any of CERAD parameters following 6 or 18 months of treatment. These data support previous observations that donepezil therapy is effective in AD patients with and without subcortical vascular lesions.


  

Author Contacts

Josef Marksteiner, MD
Department of Psychiatry
Medical University of Innsbruck
Anichstrasse 35, AT–6020 Innsbruck (Austria)
Tel. +43 512 507 3639, Fax +43 512 507 4571, E-Mail J.Marksteiner@uibk.ac.at

  

Article Information

Received: January 27, 2004
Accepted after revision: February 23, 2004
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 2, Number of References : 18

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)
Founded 1959 as ‘Medicina Experimentalis’, continued 1965–1967 as ‘Medicina et Pharmacologia Experimentalis’; Founder: R. Domenjoz (1959–1977); Successors: B.B. Brodie (1968–1977); K. Lederis (1973–1985); K.-F. Sewing (1978–1998); E.S. Vesell (1970–2000)

Vol. 72, No. 1, Year 2004 (Cover Date: August 2004)

Journal Editor: J. Donnerer, Graz; M.L. Billingsley, Hershey, Pa.; T. Iijima, Akita
ISSN: 0031–7012 (print), 1423–0313 (Online)

For additional information: http://www.karger.com/pha


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 1/27/2004
Accepted: 3/23/2004
Published online: 8/6/2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.