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Vol. 72, No. 1, 2004
Issue release date: August 2004
Section title: Original Paper
Pharmacology 2004;72:51–56
(DOI:10.1159/000078632)

Itch-Scratch Responses Induced by Lysophosphatidic Acid in Mice

Hashimoto T. · Ohata H. · Momose K.
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/21/2003
Accepted: 2/12/2004
Published online: 8/6/2004

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

The present investigation was conducted in order to determine whether lysophosphatidic acid (LPA) induces itch-scratch responses (ISRs) in mice. Intradermal administration of LPA induces ISRs; furthermore, the time course for LPA-induced ISRs was similar to that for histamine-induced responses. Comparative study of the pruritogenic activity revealed that histamine possessed a potent effect characterized by a dose-response relationship; however, prostaglandin D2 failed to induce this response. Pretreatment with ketotifen, a histamine H1 receptor antagonist, and capsaicin inhibited LPA-induced ISRs. Additionally, LPA-induced ISRs were abolished by Y-27632, an inhibitor of Rho-associated protein kinase (ROCK). These findings suggest that LPA-induced ISRs are attributable to histamine- and substance-P-mediated pathways. Moreover, the Rho/ROCK-mediated pathway may be involved.


  

Author Contacts

Hisayuki Ohata
1-5-8 Hatanodai, Shinagawa-ku
Tokyo 142-8555 (Japan)
Tel. +81 3 3784 8212, Fax +81 3 3784 3232
E-Mail ohata@pharm.showa-u.ac.jp

  

Article Information

Received: August 21, 2003
Accepted after revision: February 12, 2004
Number of Print Pages : 6
Number of Figures : 5, Number of Tables : 0, Number of References : 30

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)

Vol. 72, No. 1, Year 2004 (Cover Date: September 2004)

Journal Editor: Donnerer, J. (Graz)
ISSN: 0031–7012 (print), 1423–0313 (Online)

For additional information: http://www.karger.com/pha


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/21/2003
Accepted: 2/12/2004
Published online: 8/6/2004

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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