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Vol. 134, No. 3, 2004
Issue release date: July 2004
Section title: Review
Int Arch Allergy Immunol 2004;134:186–198
(DOI:10.1159/000078765)

T Lymphocyte-Mediated Immune Responses to Chemical Haptens and Metal Ions: Implications for Allergic and Autoimmune Disease

Martin S.F.
Clinical Research Group Allergology, Department of Dermatology, University of Freiburg, Freiburg, Germany

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 2/2/2004
Accepted: 3/30/2004
Published online: 6/28/2004
Issue release date: July 2004

Number of Print Pages: 13
Number of Figures: 4
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Chemical haptens and metal ions interact with proteins and thereby become recognizable by T and B lymphocytes. They induce the production of proinflammatory cytokines and chemokines by various cell types due to triggering of innate immune responses. This is an important prerequisite for the activation of the adaptive immune system and the development of diseases like allergic contact dermatitis and adverse drug and autoimmune reactions. Our increasing knowledge about the molecular basis of hapten and metal ion recognition by T cells and about the pathomechanisms of contact hypersensitivity and chemical-induced autoimmune reactions allows concomitant progress in the development of modern strategies for immunotherapy and will hopefully enable more specific intervention in hapten- and metal ion-induced human diseases in the future.

© 2004 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Dr. Stefan F. Martin
Department of Dermatology, Clinical Research Group Allergology
University of Freiburg, Hauptstrasse 7
DE–79104 Freiburg (Germany)
Tel. +49 761 270 6738, Fax +49 761 270 6655, E-Mail martin@haut.ukl.uni-freiburg.de

  

Article Information

Published online: June 1, 2004
Number of Print Pages : 13
Number of Figures : 4, Number of Tables : 0, Number of References : 171

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950
Official Journal of the Collegium Internationale Allergologicum

Vol. 134, No. 3, Year 2004 (Cover Date: July 2004)

Journal Editor: R. Valenta, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 2/2/2004
Accepted: 3/30/2004
Published online: 6/28/2004
Issue release date: July 2004

Number of Print Pages: 13
Number of Figures: 4
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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