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Table of Contents
Vol. 19, No. 5, 2004
Issue release date: September – October
Section title: Paper
Fetal Diagn Ther 2004;19:404–409
(DOI:10.1159/000078992)

HLA-G Antigen and Parturition: Maternal Serum, Fetal Serum and Amniotic Fluid Levels during Pregnancy

Hackmon R.a · Hallak M.a · Krup M.b · Weitzman D.c · Sheiner E.a · Kaplan B.a,d · Weinstein Y.b
Departments of aObstetrics and Gynecology, bImmunology, and cEpidemiology and Health Services Evaluation, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, and dDepartment of Obstetrics and Gynecology of Beilinson Medical Center, Petach Tikva, Israel

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: January 13, 2003
Accepted: July 30, 2003
Published online: August 12, 2004
Issue release date: September – October

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: To determine whether soluble HLA-G1 (sHLA-G1) concentrations in maternal serum and in amniotic fluid are lower at term than in the second trimester. Methods: In this prospective study amniotic fluid and maternal serum samples were aspirated from 21 pregnant women during genetic amniocentesis at 16–20 weeks’ gestation, and from 19 women undergoing a cesarean section at term. In the latter group arterial umbilical cord blood was aspirated as well. sHLA-G1 levels were determined using ELISA assay. This assay included the anti-HLA-G monoclonal antibodies 87G and 16G1, both as capture antibodies and horseradish-peroxidase-labeled rabbit anti-human β2-microglobulin antibodies, as the detection antibody. The relative concentrations of sHLA-G1 were measured from the absorbancy of the blue product at 650 nm. Student’s t test was used for statistical analysis. Results: sHLA-G1 levels in amniotic fluid were significantly lower at term than in the second trimester (0.160 ± 0.05 vs. 0.272 ± 0.150 OD units; p < 0.05). Levels of sHLA-G1 in maternal serum declined toward term, but the difference from the second trimester was not statistically significant (0.266 ± 0.157 vs. 0.205 ± 0.120 OD units; p = 0.193). There was a strong correlation of sHLA-G1 concentrations between cord serum and maternal serum (R2 = 0.79; p < 0.001), but not between cord serum and amniotic fluid (R2 = 0.00004) or amniotic fluid and maternal serum (R2 = 0.02). Conclusions: sHLA-G1 antigen expression is higher in amniotic fluid than in maternal-fetal compartments and significantly decreases toward term. We speculate that the declining amniotic fluid sHLA-G1 levels may stimulate a maternal immunological response against the fetus and contribute to the initiation of parturition.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: January 13, 2003
Accepted: July 30, 2003
Published online: August 12, 2004
Issue release date: September – October

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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