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Vol. 50, No. 2, 2004
Issue release date: July 2004
Section title: Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2004;50:153–156
(DOI:10.1159/000079107)

Association Study of Catechol- O-Methyltransferase Gene and Dopamine D4 Receptor Gene Polymorphisms and Personality Traits in Healthy Young Chinese Females

Tsai S.-J. · Hong C.-J. · Yu Y.W.-Y. · Chen T.-J.
aDepartment of Psychiatry, Taipei Veterans General Hospital, bDivision of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, cYu’s Psychiatric Clinic, dKai-Suan Psychiatric Hospital, and eDepartment of Psychiatry, E-Da Hospital, Kaohsiung, Taiwan, ROC

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 7/29/2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Human personality traits, which are substantially heritable, may be modulated by monoamine neurotransmitters. It has been demonstrated that the catechol-O-methyltransferase (COMT) Val158Met genetic polymorphism, a functional polymorphism that may affect monoamine metabolism, is possibly associated with specific personality traits. In addition, a polymorphism in the dopamine D4 receptor (DRD4) gene exon 3 has been associated in some, but not all, studies with the novelty seeking personality trait, as evaluated by the Tridimensional Personality Questionnaire (TPQ). In this study, associations between these two polymorphisms and TPQ personality traits were investigated in a sample population of 120 healthy young Chinese females. The results of this analysis reveal that the COMT Val158Met polymorphism was significantly associated with novelty seeking (p = 0.017) and reward dependence scores (p = 0.015) in our sample. However, no significant differences were demonstrated comparing TPQ-specific scores for subjects bearing different DRD4 genotypes. The present study suggests that the functional COMT Val158Met genetic polymorphism contributes to individual differences in the personality traits novelty seeking and reward dependence. Similar to the results of a recent meta-analytic review, however, no association was demonstrated between this DRD4 polymorphism and novelty seeking in our young Chinese female sample population.


  

Author Contacts

Shih-Jen Tsai, MD
Department of Psychiatry, Taipei Veterans General Hospital
No. 201 Shih-Pai Road, Sec. 2, 11217
Taipei, Taiwan (ROC)
Tel. +886 2 2875 7027, ext. 276, Fax +886 2 2872 5643, E-Mail sjtsai@vghtpe.gov.tw

  

Article Information

Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 22

  

Publication Details

Neuropsychobiology
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)

Vol. 50, No. 2, Year 2004 (Cover Date: Released July 2004)

Journal Editor: P. Netter, Giessen; J. Mendlewicz, Brussels; B. Saletu, Vienna
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/nps


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 7/29/2004

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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