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Table of Contents
Vol. 18, No. 2, 2004
Issue release date: August 2004
Section title: Original Research Article
Dement Geriatr Cogn Disord 2004;18:125–131
(DOI:10.1159/000079191)

Apolipoprotein E ε4 Allele Differently Affects the Patterns of Neuropsychological Presentation in Early- and Late-Onset Alzheimer’s Disease Patients

Marra C.a · Bizzarro A.a · Daniele A.a · De Luca L.a · Ferraccioli M.a · Valenza A.a · Brahe C.b · Tiziano F.D.b · Gainotti G.a · Masullo C.a
aDepartment of Neurology and bInstitute of Medical Genetics, Catholic University of Rome, Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: December 10, 2003
Published online: August 13, 2004
Issue release date: August 2004

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

The presence of the apolipoprotein E (APOE) Ε4 allele is a definite risk factor for the onset of Alzheimer’s disease (AD). Its presence seems to affect especially the memory in the early stage of the disease, but the effect on the progression of the disease and survival is still controversial. Some longitudinal studies could be influenced by variables other than APOE, such as the response to medical treatment, rehabilitation therapy and inclusion of patients at different stages of progression at baseline. Moreover, the inclusion in the same study sample of patients of different ages at onset of the disease (below 65 or above 80 years) appears arbitrary. In our study, we evaluated a population of newly diagnosed untreated AD patients at their first neuropsychological examination and with the onset of their first symptoms not longer than 3 years ago. In order to analyse the different effects of the APOE Ε4 allele on the different ages at the onset of the disease, we split the study sample into two groups: (1) subjects under 65 years [early-onset AD (EOAD); n = 30] and subjects over 70 years [late-onset AD (LOAD); n = 41], excluding subjects with an age of onset between 66 and 69 years. Our results show that the APOE Ε4 allele carriers are characterised by a different neuropsychological pattern at the disease onset; however, only in the EOAD group is this effect significant: in EOAD, the Ε4 allele carriers obtained worse performances in learning, long-term verbal memory and general intelligence tasks. On the contrary, in LOAD patients, the pattern of cognitive impairment at the onset is not dependent on the possession of an Ε4 allele in the genotype. Such data could suggest a careful control of the study sample concerning age at the onset of the disease since APOE could play a different role in EOAD and LOAD mainly due to the different pathogenic mechanism at the onset and evolution of AD.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: December 10, 2003
Published online: August 13, 2004
Issue release date: August 2004

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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