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Vol. 41, No. 4, 2004
Issue release date: July–August 2004
Section title: Research Paper
J Vasc Res 2004;41:314–322
(DOI:10.1159/000079205)

Altered Vascular Remodeling in Osteopontin-Deficient Atherosclerotic Mice

Ström Å. · Franzén A. · Wängnerud C. · Knutsson A.-K. · Heinegård D. · Hultgårdh-Nilsson A.
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, Lund, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 12/8/2003
Accepted: 4/30/2004
Published online: 9/30/2004
Issue release date: July–August 2004

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Background: Osteopontin (OPN) is a cell-binding phosphoprotein with proposed functions in atherosclerosis. The aim of this study was to examine how OPN deficiency affects the atherosclerotic process. Methods: ApoE/LDL receptor/OPN triple knockout (ALO) mice were generated by crossing OPN null mice with ApoE/LDL receptor-deficient (AL) mice. Analysis were made on tissue sections from the aortic arch of 8-, 20- and 34-week female AL and ALO mice and included morphometric measurements, collagen staining, TUNEL staining and immunohistochemistry with antibodies to OPN, macrophages and proliferating cellular nuclear antigen (PCNA). Results: Lesion and media areas were significantly smaller and collagen accumulation in lesions was significantly reduced in 34-week-old ALO mice compared with AL mice. The numbers of proliferating and apoptotic cells were increased in lesions of 34 weeks old ALO mice. Furthermore, the plasma levels of SAA and total cholesterol were significantly decreased in 34 weeks old ALO mice. Conclusions: The present study shows that OPN deficiency reduces atherogenesis in atherosclerotic mice. The results corroborate and extend recently published findings and also include novel data on the role of OPN in the process of remodeling, inflammation and lipid metabolism.

© 2004 S. Karger AG, Basel


  

Author Contacts

Anna Hultgårdh-Nilsson
Department of Cell and Molecular Biology
Section for Connective Tissue Biology, Lund University
BMC, C12, SE-221 84 Lund (Sweden)
Tel. +46 46 2229673, Fax +46 46 2113417, E-Mail anna.hultgardh@medkem.lu.se

  

Article Information

Received: December 8, 2003
Accepted after revision: April 30, 2004
Published online: June 21, 2004
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 4, Number of References : 37

  

Publication Details

Journal of Vascular Research (Incorporating International Journal of Microcirculation)
Founded 1964 as Angiologica by M. Comèl and L. Laszt (1964–1973) continued as Blood Vessels by J.A. Bevan (1974–1991)
Official Journal of the European Society for Microcirculation

Vol. 41, No. 4, Year 2004 (Cover Date: July-August 2004)

Journal Editor: U. Pohl, Munich
ISSN: 1018–1172 (print), 1423–0135 (Online)

For additional information: http://www.karger.com/jvr


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Received: 12/8/2003
Accepted: 4/30/2004
Published online: 9/30/2004
Issue release date: July–August 2004

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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