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Table of Contents
Vol. 62, No. 2, 2004
Issue release date: September 2004
Section title: Original Paper
Horm Res 2004;62:71–78
(DOI:10.1159/000079326)

Impact of Meal Timing and Frequency on the Twenty-Four-Hour Leptin Rhythm

Fogteloo A.J.a · Pijl H.a · Roelfsema F.a · Frölich M.b · Meinders A.E.a
Departments of aGeneral Internal Medicine and bClinical Chemistry, Leiden University Medical Center, Leiden, TheNetherlands

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/28/2003
Accepted: 4/20/2004
Published online: 9/13/2004
Issue release date: September 2004

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 4

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Objective: To study the influence of changes in meal timing and frequency on the diurnal rhythm of leptin and on the 24-hour profile of insulin and glucose. Patients and Methods: Five obese women were studied twice during a weight-maintaining diet in either 3 daily or 8 day and night equal portions. Blood was sampled for 24-hour profiles of leptin and insulin. Results: During the 8-meal intervention, the 24-hour rhythm of leptin changed significantly: the amplitude decreased (p = 0.0089) and the acrophase was delayed by 168 min (p = 0.021). Also, 8 small insulin secretion peaks occurred instead of the 3 postprandial high insulin peaks. Conclusion: The dispersion of food intake over 24 h affects the diurnal leptin rhythm. These changes could not be attributed to changes in circadian timing or energy balance. Instead, changes in daily insulin secretion profiles might play a role.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/28/2003
Accepted: 4/20/2004
Published online: 9/13/2004
Issue release date: September 2004

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 4

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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