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Table of Contents
Vol. 66, No. 6, 2004
Issue release date: September 2004
Section title: Laboratory/Clinical Translational Research
Oncology 2004;66:450–457
(DOI:10.1159/000079499)

Coexpression of Gas6/Axl in Human Ovarian Cancers

Sun W. · Fujimoto J. · Tamaya T.
Departmentof Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan

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Article / Publication Details

First-Page Preview
Abstract of Laboratory/Clinical Translational Research

Received: July 14, 2003
Accepted: November 21, 2003
Published online: September 24, 2004
Issue release date: September 2004

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objectives: Gas6, the protein product of the growth arrest-specific gene 6 (gas6), a member of the vitamin K-dependent protein family, was identified as a ligand for the Axl/Sky family of receptor tyrosine kinases. The aim is to study for the presence of Gas6 and its receptor Axl and Sky related to specific growth in the ovarian cancers, and to evaluate their plausible growth potential and mechanism. Methods: In ovarian cancers of 90 cases, the histoscores and mRNA levels of Gas6, Axl and Sky were determined by immunohistochemistry and competitive reverse transcription-polymerase chain reaction-Southern blot analysis using the recombinant RNA, respectively. Results: The histoscores and mRNA levels of Gas6 and Axl in ovarian cancers were significantly higher than in normal ovaries, regardless of histopathological type or clinical stage of ovarian cancers. Conclusions: Gas6/Axl pathway could play a role in the complex events taking place during the early changes of ovarian cancer progression.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Laboratory/Clinical Translational Research

Received: July 14, 2003
Accepted: November 21, 2003
Published online: September 24, 2004
Issue release date: September 2004

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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