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Vol. 71, No. 4, 2004
Issue release date: July–August 2004
Section title: Clinical Investigations
Respiration 2004;71:348–352
(DOI:10.1159/000079638)

A Normal FEV1/VC Ratio Does Not Exclude Airway Obstruction

Stănescu D. · Veriter C.
Pulmonary Laboratory and Division, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 1/29/2004
Accepted: 3/5/2004
Published online: 8/13/2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: A decreased forced expiratory volume in 1 s/vital capacity (FEV1/VC) ratio is the hallmark of the definition of airway obstruction. We recently suggested that a lung function pattern, we called small airways syndrome (SAOS), has a normal FEV1/VC and total lung capacity (TLC) and reflects obstruction of small airways. Objectives: To substantiate our hypothesis we measured and compared lung function tests including maximal expiratory flow rates (MEFR), sensitive indicators of airway obstruction, in SAOS subjects and in matched controls. Methods: We selected 12 subjects with the pattern of SAOS, but without chronic lung or heart disease (average age: 40.7 ± 7.8 years) and 36 age-matched subjects with normal lung function (42.8 ± 6.3 years). We measured static and dynamic lung volumes, MEFR and lung diffusing capacity (DLCO). Results: SAOS subjects were heavier smokers (p < 0.05) and body mass index was less than in control subjects (p < 0.01). Both FEV1/VC ratio and TLC were comparable in the two groups. However, FEV1, VC, DLCO, and MEFR were lower and residual volume (RV) and RV/TLC ratio were higher (p < 0.05) in the SAOS group than in the control one. Furthermore, the MEFR curve of the SAOS group was displaced to the left without any change in slope, suggesting premature airway closure. Conclusion: Our results suggest that a normal FEV1/VC ratio does not exclude airway obstruction. A decrease of FEV1, provided TLC is normal, reflects small airway obstruction.


  

Author Contacts

Dan Stănescu, MD, PhD
Av de la Chapelle 132
BE–1950 Kraainem (Belgium)
Tel./Fax +32 2 7207387
E-Mail stanescu@pneu.ucl.ac.be

  

Article Information

Received: January 29, 2004
Accepted: March 5, 2004
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 1, Number of References : 24

  

Publication Details

Respiration (International Review of Thoracic Diseases)
Founded 1944 as ‘Schweizerische Zeitschrift für Tuberkulose und Pneumonologie’ by E. Bachmann, M. Gilbert, F. Häberlin, W. Löffler, P. Steiner and E. Uehlinger, continued 1962–1967 as ‘Medicina Thoracalis’ as of 1968 as ‘Respiration’, H. Herzog (1962–1997)
Official Journal of the European Association for Bronchology and Interventional Pulmonology

Vol. 71, No. 4, Year 2004 (Cover Date: July-August 2004)

Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/journals/res


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 1/29/2004
Accepted: 3/5/2004
Published online: 8/13/2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 1

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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