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Vol. 71, No. 4, 2004
Issue release date: July–August 2004
Section title: Clinical Investigations
Respiration 2004;71:360–366
(DOI:10.1159/000079640)

Isolation of Fungi, Especially Exophiala dermatitidis, in Patients Suffering from Cystic Fibrosis

A Prospective Study

Horré R. · Schaal K.P. · Siekmeier R. · Sterzik B. · de Hoog G.S. · Schnitzler N.
aInstitute for Medical Microbiology and Immunology, University of Bonn, bFederal Institute for Drugs and Medical Devices, Bonn, and cInstitute for Medical Microbiology, RWTH, Aachen, Germany; dCentraalbureau voor Schimmelcultures Utrecht, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 5/21/2003
Accepted: 1/29/2004
Published online: 8/13/2004

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: Patients with cystic fibrosis (CF) are at an increased risk of pulmonary colonisation by opportunistic micro-organisms. Using specialised methods, the black yeast Exophiala dermatitidis could consistently be cultured from CF patients. Isolation rates from sputum samples ranged between 1.8 and 15.7%. Occasionally, infection could be recognised. Objectives: This study aimed at investigating the isolation rates of E. dermatitidis in samples taken from CF patients at the University of Bonn, Germany. Methods: Altogether, 439 respiratory specimens taken from 81 CF patients were screened for the occurrence of E. dermatitidis over a period of 18 months. For the selective isolation of this fungus erythritol-chloramphenicol agar (ECA) produced in house was applied. Results: The isolation rate of E. dermatitidis was 1.1% from all specimens, 1.6% from all sputum samples and 6.2% in all patients examined. Conclusions: Prior to the introduction of ECA, E. dermatitidis had never been isolated in our laboratory, either from CF, or from any other patient. During this study, E. dermatitidis was found to colonise the respiratory tract of some CF patients. The use of additional selective culture media is necessary for the recognition of uncommon fungi, e.g. E. dermatitidis, in CF patients.


  

Author Contacts

Dr. med. Regine Horré
Federal Institute for Drugs and Medical Devices
Kurt-Georg-Kiesinger-Allee 3
DE–53175 Bonn (Germany)
Tel. +49 228 207 3267, E-Mail horre@bfarm.de

  

Article Information

Received: May 21, 2003
Accepted after revision: January 29, 2004
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 4, Number of References : 26

  

Publication Details

Respiration (International Review of Thoracic Diseases)
Founded 1944 as ‘Schweizerische Zeitschrift für Tuberkulose und Pneumonologie’ by E. Bachmann, M. Gilbert, F. Häberlin, W. Löffler, P. Steiner and E. Uehlinger, continued 1962–1967 as ‘Medicina Thoracalis’ as of 1968 as ‘Respiration’, H. Herzog (1962–1997)
Official Journal of the European Association for Bronchology and Interventional Pulmonology

Vol. 71, No. 4, Year 2004 (Cover Date: July-August 2004)

Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/journals/res


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 5/21/2003
Accepted: 1/29/2004
Published online: 8/13/2004

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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