Specific Functional Effects of Memantine Treatment in Patients with Moderate to Severe Alzheimer’s DiseaseDoody R. · Wirth Y. · Schmitt F. · Möbius H.J.
Departments of aNeurology, Baylor College of Medicine, Houston, Tex., and bNeurology and Psychiatry, University of Kentucky, Lexington, Ky., USA; cMerz Pharmaceuticals GmbH, Frankfurt, Germany
Treatment of Alzheimer’s disease (AD) that combats progressive functional deterioration can improve the patient’s quality of life and reduce caregiver burden. Memantine, a moderate affinity N-methyl-D-aspartate receptor antagonist, reduces global deterioration in AD patients and provides cognitive and functional benefits relative to placebo. Two previous studies reported statistically significant benefits of memantine for overall functional ability on the Alzheimer Disease Cooperative Study Activities of Daily Living Inventory modified for severe dementia (ADCS-ADL19), Functional Assessment Staging, and G2 scale. The present study reports a single-item analysis of the ADL scales from the two trials and shows that patients treated with memantine demonstrated a numerical advantage over placebo on all items assessed. These results help to translate the positive effects of memantine into specific aspects of functional ability, information that is relevant to AD patients and their families as well as to researchers interested in the assessment of functional ability in AD clinical trials.
Rachelle Doody, MD, PhD
Baylor College of Medicine, Department of Neurology
6550 Fannin, Suite 1801
Houston, TX 77030 (USA)
Tel. +1 713 798 7416, Fax +1 713 798 5326, E-Mail firstname.lastname@example.org
Accepted: June 4, 2004
Published online: July 14, 2004
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 1, Number of References : 18
Dementia and Geriatric Cognitive Disorders
Vol. 18, No. 2, Year 2004 (Cover Date: Released August 2004)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem