A 42-year-old man had a large speckled lentiginous nevus on the left side of his trunk. The involved area was painful when touched and paresthetic. Moreover, the ipsilateral half of his body showed a pronounced hyperhidrosis. This case can be categorized as a typical example of speckled lentiginous nevus syndrome, a recently recognized phenotype characterized by a speckled lentiginous nevus of the papular type and ipsilateral neurological abnormalities in the form of dysesthesia, muscular weakness or hyperhidrosis. Speckled lentiginous nevus syndrome represents a mosaic phenotype. Most likely it originates from loss of heterozygosity occurring in a heterozygous embryo at an early developmental stage.
Dr. Rudolf Happle
Department of Dermatology, Philipp University of Marburg
DE–35033 Marburg (Germany)
Tel. +49 6421 286 6280, Fax +49 6421 286 2902, E-Mail firstname.lastname@example.org
Received: January 28, 2004
Accepted: May 2, 2004
Number of Print Pages : 2
Number of Figures : 3, Number of Tables : 1, Number of References : 15
Dermatology (International Journal for Clinical and Investigative Dermatology)
Vol. 209, No. 3, Year 2004 (Cover Date: 2004)
Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)
For additional information: http://www.karger.com/drm
Article / Publication Details
Published online: 9/24/2004
Number of Print Pages: 2
Number of Figures: 3
Number of Tables: 1
ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)
For additional information: http://www.karger.com/DRM
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