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Vol. 86, No. 4, 2004
Issue release date: November 2004
Section title: Original Paper
Biol Neonate 2004;86:247–253
(DOI:10.1159/000079907)

Benign B-Cell Precursors (Hematogones) Are the Predominant Lymphoid Population in the Bone Marrow of Preterm Infants

Rimsza L.M. · Douglas V.K. · Tighe P. · Saxonhouse M.A. · Calhoun D.A. · Christensen R.D. · Sola M.C.
aDepartment of Pathology, University of Arizona, Tucson, Ariz., bDepartment of Pathology, Immunology and Laboratory Medicine, cCollege of Medicine, dDepartment of Pediatrics, University of Florida, Gainesville, Fla. and eDepartment of Pediatrics, University of South Florida and All Children’s Hospital, St. Petersburg, Fla., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/27/2003
Accepted: 5/3/2004
Published online: 11/12/2004

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Bone marrow (BM) findings in 3rd-trimester stillborns and full-term living neonates have been previously described. However, there is no information regarding BM composition in living preterm infants. Specifically, it is unknown whether the BM lymphocytosis seen in full-term infants at 1–4 weeks of age also occurs in preterm infants. Furthermore, the lineage of these cells has never been investigated. We used a panel of immunohistochemical stains to characterize the BM composition in 11 neonates (8 living and 3 deceased). Unlike in the other age groups, immature B cells (hematogones) were the most common lymphoid population, accounting for 10–60% (mean 34%) of all cells. In two additional cases (both living patients), flow cytometry revealed a level of 3.8% of immature B cells in a <1-week-old neonate and 25.7% in a 19-week-old infant. Immature B cells were not identified in 6 peripheral blood samples from preterm neonates. These findings are pertinent for the interpretation of BM and peripheral blood samples in this age group as survival improves and diagnostic samples become more common.


  

Author Contacts

Lisa M. Rimsza, MD
Department of Pathology, College of Medicine, University of Arizona
1501 N. Campbell Road
Tucson, AZ 85724 (USA)
Tel. +1 520 626 6096, Fax +1 520 626 5243, E-Mail rimsza@ahsc.arizona.edu

  

Article Information

Received: October 27, 2003
Accepted after revision: May 3, 2004
Published online: July 21, 2004
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 3, Number of References : 15

  

Publication Details

Biology of the Neonate (Foetal and Neonatal Research)

Vol. 86, No. 4, Year 2004 (Cover Date: Released November 2004)

Journal Editor: J.P. Relier, Paris
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/bon


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/27/2003
Accepted: 5/3/2004
Published online: 11/12/2004

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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