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Vol. 62, No. 3, 2004
Issue release date: September 2004
Section title: Original Paper
Horm Res 2004;62:142–148
(DOI:10.1159/000080070)

Assessment of Hepatic Glucose Metabolism by Indirect Calorimetry in Combination with a Non-Invasive Technique Using Naturally Enriched 13C Glucose in Healthy Children and Adolescents

Selz R. · Jornayvaz F.R. · Tappy L. · Woringer V. · Theintz G.E.
aEndocrinology and Diabetology Unit, Department of Pediatrics, University Hospital Center; bInstitute of Physiology, University of Lausanne Medical School, and cDepartment of Public Education, School Health Services, Lausanne, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/11/2003
Accepted: 5/11/2004
Published online: 9/10/2004

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

The metabolic fate of hepatic glucose can be best studied using invasive techniques such as tracer infusions and frequent blood sampling which have been revealed to be impractical in the pediatric age group. The aim of this study was to develop a non-invasive method based on indirect calorimetry and expired 13CO2 monitoring in order to gain insight into the mechanisms leading to impaired glucose tolerance in children and teenagers. As a first step, net glucose oxidation (NGO) and energy expenditure (EE) were measured in 47 subjects (range 7.5–17.3 years) of whom 18 were prepubertal (P1), 11 in early puberty (P2–P3) and 18 in late puberty (P4–P5) after 3-hourly loads of 180 mg/kg of oral maize glucose containing naturally enriched 13C. Isotope analysis allowed to calculate exogenous and endogenous glucose oxidation (EXGO, ENGO) and, hence, to derive TGS and NGS, that is glycogen turnover. NGO and EE decreased significantly with pubertal progression, reflecting higher metabolism at younger ages, whereas EXGO remained constant. TGS did not change significantly whereas NGS showed a significant negative correlation with pubertal progression: this can be explained by the fact that glycogenolysis exceeded glycogen synthesis in this experimental setting. This non-invasive method appears to be a promising tool to study the fate of hepatic glucose and therefore glycogen turnover in children at risk of developing glucose intolerance and/or type 2 diabetes.


  

Author Contacts

Gérald E. Theintz, MD
Endocrinology and Diabetology Unit
Department of Pediatrics, University Hospital Center
CH–1011 Lausanne (Switzerland)
Tel. +41 216 27 27 52, Fax +41 216 27 27 59, E-Mail gerald.theintz@enf.hospvd.ch

  

Article Information

Received: September 11, 2002
Accepted after revision: May 11, 2004
Published online: August 4, 2004
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 2, Number of References : 37

  

Publication Details

Hormone Research (International Journal of Experimental and Clinical Endocrinology)
Founded 1970 as ‘Hormones’ by M. Marois, Continued 1976 by J. Girard (1976–1995)
Official Organ of the European Society for Paediatric Endocrinology

Vol. 62, No. 3, Year 2004 (Cover Date: Released September 2004)

Journal Editor: M.B. Ranke, Tübingen
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/journals/hre


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/11/2003
Accepted: 5/11/2004
Published online: 9/10/2004

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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