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Vol. 70, No. 1, 2004
Issue release date: 2004
Section title: Original Paper
Digestion 2004;70:49–54
(DOI:10.1159/000080081)

Inflammatory Bowel Disease-Specific Autoantibodies in HLA-B27-Associated Spondyloarthropathies: Increased Prevalence of ASCA and pANCA

Török H.-P. · Glas J. · Gruber R. · Brumberger V. · Strasser C. · Kellner H. · Märker-Hermann E. · Folwaczny C.
aMedizinische Poliklinik, bChirurgische Klinik und Poliklinik, Standort Innenstadt, Ludwig-Maximilians-Universität, München, und cKlinik Innere Medizin IV, Dr.-Horst-Schmidt-Kliniken, Wiesbaden, Deutschland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/16/2003
Accepted: 6/22/2004
Published online: 9/1/2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Aims: An association between inflammatory bowel disease (IBD) and spondyloarthropathies (SpA) has repeatedly been reported. The aim of the present study was to investigate whether serologic markers of IBD, e.g. antibodies against Saccharomyces cerevisiae (ASCA), antibodies against exocrine pancreas (PAB) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) are present in HLA-B27-associated SpA. Methods: 87 patients with HLA-B27-positive SpA and 145 controls were tested for ASCA, PAB and pANCA employing ELISA or indirect immunofluorescence, respectively. Antibody-positive patients were interviewed regarding IBD-related symptoms using a standardized questionnaire. Results/Conclusion: When compared to the controls, ASCA IgA but not ASCA IgG levels were significantly increased in patients with SpA, in particular in ankylosing spondylitis (AS) and undifferentiated SpA (uSpA). pANCA were found in increased frequency in patients with SpA whereas PAB were not detected. The existence of autoantibodies was not associated with gastrointestinal symptoms but sustains the presence of a pathophysiological link between bowel inflammation and SpA.


  

Author Contacts

PD Dr. med. Christian Folwaczny
Medizinische Poliklinik, Ludwig-Maximilians-Universität München
Nussbaumstrasse 20, DE–80336 München (Germany)
Tel. +49 89 5160 2625, Fax +49 89 5160 4187
E-Mail christian.folwaczny@medinn.med.uni-muenchen.de

  

Article Information

Received: October 16, 2003
Accepted: June 22, 2004
Published online: August 11, 2004
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 1, Number of References : 42

  

Publication Details

Digestion (International Journal of Gastroenterology)
Founded as Archiv für Verdauungskrankheiten, 1895; continued as Gastroenterologia, 1939-1967

Vol. 70, No. 1, Year 2004 (Cover Date: 2004)

Journal Editor: R. Arnold, Marburg
ISSN: 0012–2823 (print), 1421–9867 (Online)

For additional information: http://www.karger.com/journals/dig


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/16/2003
Accepted: 6/22/2004
Published online: 9/1/2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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