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Vol. 41, No. 2, 1999
Issue release date: February 1999
Section title: Original Paper
Eur Neurol 1999;41:88–93
(DOI:10.1159/000008009)

Lysine-Acetylsalicylic Acid in Acute Migraine Attacks

Limmroth V. · May A. · Diener H.-C.
Neurologische Universitätsklinik Essen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/19/1999
Issue release date: February 1999

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Vasoconstrictive agents have been widely used in the treatment of migraine. These types of drugs have various side effects and are not suitable for many patients. Due to nausea or vomiting, nonoral treatment is often required, but only a few nonvasoconstrictive drugs exist in a parenteral form and are suitable for the treatment of acute migraine in the emergency setting. In a randomized, double-blind, crossover trial we evaluated the efficacy of 1,000 mg lysine-acetylsalicylic acid i.v. (LAS) compared to 0.5 mg ergotamine s.c. in 56 patients (112 attacks) with acute migraine. To gain further insight into the possible role of vasoconstriction, blood flow velocities (BFV) were measured in intra- and extracranial arteries using duplex sonography and transcranial Doppler sonography. Both agents were equally potent in relieving headache. Intravenous LAS resulted in a significantly faster relief and had fewer side effects. LAS had no effect on BFV. Ergotamine increased BFV in the middle cerebral artery only. No correlation was found between changes in BFV and the relief of headache. This is the first trial to compare the intravenous formulation of LAS in the treatment of migraine with another antimigraine medication and suggests that it is an effective and safe drug for the parenteral treatment of acute migraine attacks.


  

Author Contacts

Prof. Dr. Hans-Christoph Diener
Department of Neurology, School of Medicine
University of Essen, Hufelandstrasse 55
D–45122 Essen (Germany)
Tel. +49 201 723 2461, Fax +49 201 723 5901

  

Article Information

Received: Received: May 6, 1998
Accepted: September 18, 1998
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 17

  

Publication Details

European Neurology
Founded 1897 as ‘Monatsschrift für Psychiatrie und Neurologie’

Vol. 41, No. 2, Year 1999 (Cover Date: Released February 1999)

Journal Editor: J. Bogousslavsky, Lausanne
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/journals/ene


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/19/1999
Issue release date: February 1999

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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