Conversion to Dementia among Two Groups with Cognitive Impairment
A Preliminary ReportLuis C.A.a,b · Barker W.W.a · Loewenstein D.A.a,b · Crum T.A.a,b · Rogaeva E.d · Kawarai T.d · St. George-Hyslop P.d · Duara R.a-c
aWien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center, Departments of bPsychiatry and Behavioral Sciences and cMedicine, University of Miami School of Medicine, Miami, Fla., USA; dDepartment of Medicine and Physiology, Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada
Objective: To determine the conversion rates to dementia in patients diagnosed with mild cognitive impairment (MCI) thought to be caused by incipient Alzheimer’s disease (MCI-AD) or with MCI with features of vascular disease (MCI-Vas). Methods: On the basis of patient history, neurocognitive, neurological and MRI evaluation, 99 patients were diagnosed with MCI-AD and 35 with MCI-Vas. Conversion to dementia over an average of a 2.4 ± 1.8-year period was determined. Results: Over the follow-up period, 44% converted to dementia, 51.5% remained classified as MCI, and 4.5% were reclassified as cognitively normal. The conversion rate to dementia was significantly faster at 3 years for the MCI-AD (50.5%) than for the MCI-Vas group (25.7%). The neuropsychological test found to best differentiate converters from non-converters was the Fuld-OME, a measure of learning and recall. Age, education, gender or APOE ε4 allele frequency did not differentiate converters from non-converters. Conclusions: MCI-AD and MCI-Vas are clinically meaningful subtypes of MCI that may convert to dementia at different rates. Prospective studies on larger subsets of MCI patients are required to confirm these findings.
© 2004 S. Karger AG, Basel
Dr. Cheryl A. Luis
Wien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center
4300 Alton Road, MRI Building
Miami Beach, FL 33140 (USA)
Tel. +1 305 674 2424, Fax +1 305 674 2996, E-Mail firstname.lastname@example.org
Portions of the study were presented at the 54th Annual Meeting of the American Academy of Neurology, Denver, April, 2002, and at the 8th International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, July, 2002.
Accepted: March 4, 2004
Published online: August 6, 2004
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 2, Number of References : 47
Dementia and Geriatric Cognitive Disorders
Vol. 18, No. 3-4, Year 2004 (Cover Date: Released October 2004)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/journals/dem