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Vol. 17, No. 5, 2004
Issue release date: September–October 2004
Section title: Review
Skin Pharmacol Physiol 2004;17:207–213
(DOI:10.1159/000080213)

Hyaluronic Acid in the Treatment and Prevention of Skin Diseases: Molecular Biological, Pharmaceutical and Clinical Aspects

Weindl G.a · Schaller M.b · Schäfer-Korting M.c · Korting H.C.a
aDepartment of Dermatology and Allergology, Ludwig Maximilian University, Munich, bDepartment of Dermatology, University of Tübingen, Tübingen, and cInstitute of Pharmacy, Pharmacology and Toxicology, Free University of Berlin, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 1/19/2004
Accepted: 5/3/2004
Published online: 9/27/2004
Issue release date: September–October 2004

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

The glycosaminoglycan hyaluronic acid (HA), or hyaluronan, is a major component of the extracellular matrix of skin, joints, eye and many other tissues and organs. In spite of its simple structure, HA demonstrates remarkable rheological, viscoelastic and hygroscopic properties which are relevant for dermal tissue function. Biological activities in skin, however, are also due to its interaction with various binding proteins (hyaladherins). Due to an influence on signaling pathways, HA is involved in the wound-healing process and scarless fetal healing. Increased HA concentrations have been associated with inflammatory skin diseases. In clinical trials, topical application of HA improved wound healing; in particular, acute radioepithelitis, venous leg ulcers or diabetic foot lesions responded to HA treatment. Moreover, as a topical drug delivery system for diclofenac, an HA gel has recently been approved for the treatment of actinic keratoses. Finally, chemical modifications led to new HA derivates and biomaterials, which may be introduced into therapy in the future. Therefore, ongoing research offers new horizons for the therapeutic use of this glycosaminoglycan which has been regarded as an inert structural component until recently.

© 2004 S. Karger AG, Basel


  

Author Contacts

Günther Weindl, Ludwig-Maximilians-Universität München
Klinik und Poliklinik für Dermatologie und Allergologie
Frauenlobstrasse 9–11, DE–80337 München (Germany)
Tel. +49 89 51606151, Fax +49 89 51606007
E-Mail Guenther.Weindl@lrz.uni-muenchen.de

  

Article Information

Received: January 19, 2004
Accepted after revision: May 3, 2004
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 0, Number of References : 67

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)
Formerly ‘Skin Pharmacology and Applied Skin Physiology’; Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer

Vol. 17, No. 5, Year 2004 (Cover Date: September-October 2004)

Journal Editor: J. Lademann, Berlin; Hans F. Merk, Aachen; H. Schaefer, Berlin
ISSN: 1660–5527 (print), 1660–5535 (Online)

For additional information: http://www.karger.com/spp


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 1/19/2004
Accepted: 5/3/2004
Published online: 9/27/2004
Issue release date: September–October 2004

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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