Association of Single Nucleotide Polymorphisms in the Eosinophil Peroxidase Gene with Japanese Cedar PollinosisNakamura H.a · Higashikawa F.b · Miyagawa K.c · Nobukuni Y.c · Endo T.d · Imai T.d · Ozasa K.e · Motohashi Y.f · Matsuzaki I.g · Sasahara S.g · Hatta K.h · Ogino K.i · Eboshida A.b
aDepartment of Environmental Medicine, Kochi University School of Medicine, Nankoku; bDepartment of Public Health, Graduate School of Medical and Pharmaceutical Sciences, cDepartment of Molecular Pathology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima; dDepartment of Otorhinolaryngology, Jikei University School of Medicine, Jikei; eDepartment of Social Medicine and Cultural Sciences, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kyoto; fDepartment of Public Health, Akita University School of Medicine, Akita; gInstitute of Community Medicine, University of Tsukuba, Tsukuba; hDepartment of Psychiatry, Juntendo University School of Medicine, Tokyo; iDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
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Article / Publication Details
Background: Japanese cedar pollinosis is the most common form of hay fever in spring in Japan. We have previously demonstrated that single nucleotide polymorphism Pro358Leu of exon 7 in the eosinophil peroxidase (EPO) gene is associated with cedar pollinosis, although the association has not been confirmed by analysis of the whole gene in a different population. Methods: We sequenced all exons of the EPO gene in 60 children with pollinosis and their parents using the PCR-restriction fragment length polymorphism method. Results: We found 8 polymorphisms, Ile40Met, Gln122His, Arg202Arg (A660G), Asn303Asn (C909T), Arg326Pro, Arg326His, Pro358Leu, and Asn572Ty, in the EPO gene. As a result of the transmission disequilibrium test, we recognized significant transmissions of 202Arg (660G) in exon 6 in addition to 358Leu of exon 7 in the EPO gene of affected children. Conclusions: Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis.
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