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Table of Contents
Vol. 98, No. 2, 2004
Issue release date: October 2004
Section title: Paper
Nephron Physiol 2004;98:p37–p42
(DOI:10.1159/000080262)

Macromolecules and Urolithiasis: Parallels and Paradoxes

Ryall R.L.
Department of Surgery, Flinders University School of Medicine, Flinders Medical Centre, Adelaide, Australia

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 19, 2004
Issue release date: October 2004

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2137 (Online)

For additional information: http://www.karger.com/NEP

Abstract

Long-standing interest in the possible role of macromolecules in urolithiasis stems from the observation that all human kidney stones consist of a complex amalgam of mineral and organic material. This review summarises what is currently known or is hypothesised about the influences of urinary macromolecules, especially proteins, on the formation of calcium oxalate crystals, their attachment to renal epithelial cells, and their subsequent destruction within those cells. Although a list is provided of proteins that have either been detected in stones or have been implicated by virtue of their effects on crystallization, only a select handful, which have been intensively studied, have been singled out for individual discussion. The review ends with a speculative discussion of the applicability of current knowledge to the investigation and treatment of urolithiasis.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 19, 2004
Issue release date: October 2004

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2137 (Online)

For additional information: http://www.karger.com/NEP


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