Osteopontin (OPN) is a phosphorylated protein of wide tissue distribution that is found in association with dystrophic calcification including in the organic matrix of kidney stones. It is a strong inhibitor of crystal formation and growth in vitro, but there is still debate regarding its effects upon crystal adhesion to tubular epithelial cells. In this brief review, we will outline the evidence implicating OPN in stone disease with the primary emphasis being on the interaction of OPN with calcium oxalate (CaOx), the major constituent of calcium containing stones. Finally, preliminary data is presented regarding the amounts and features of OPN present in the urine of stone formers and normal individuals.
Jack G. Kleinman, MD
Veterans Affairs Medical Center/111K
5000 W. National Avenue
Milwaukee, WI 53925 (USA)
Tel. +1 414 384 2000, ext. 42827, Fax +1 414 383 9333, E-Mail firstname.lastname@example.org
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 0, Number of References : 46
Vol. 98, No. 2, Year 2004 (Cover Date: October 2004)
Journal Editor: R.J. Unwin, London
ISSN: 0028–2766 (print), 1660–2137 (Online)
For additional information: http://www.karger.com/nep
Article / Publication Details
Published online: 10/19/2004
Issue release date: October 2004
Number of Print Pages: 1
Number of Figures: 2
Number of Tables: 0
eISSN: 1660-2137 (Online)
For additional information: http://www.karger.com/NEP
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