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Table of Contents
Vol. 73, No. 6, 2004
Issue release date: November – December
Section title: Regular Article
Psychother Psychosom 2004;73:340–343
(DOI:10.1159/000080386)

Vitamin B6 Level Is Associated with Symptoms of Depression

Hvas A.-M.a · Juul S.b · Bech P.c · Nexø E.a
aDepartment of Clinical Biochemistry, Aarhus University Hospital, AKH, bDepartment of Epidemiology and Social Medicine, Aarhus University, Aarhus, and cPsychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Regular Article

Published online: October 15, 2004
Issue release date: November – December

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS

Abstract

Background: A low level of vitamin B6 might theoretically cause depression as vitamin B6 is a cofactor in the tryptophan-serotonin pathway. In the present study, we examined the association between depression and the phosphate derivative of vitamin B6 in plasma, pyridoxal phosphate (PLP). Methods: In 140 individuals, symptoms of depression were evaluated by the Major Depression Inventory, and biochemical markers of vitamin B deficiency were measured. Results: We found that 18 (13%) individuals were depressed. A low plasma level of PLP was significantly associated with the depression score (p = 0.002). No significant association was found between depression and plasma vitamin B12 (p = 0.13), plasma methylmalonic acid (p = 0.67), erythrocyte folate (p = 0.77), and plasma total homocysteine (p = 0.16). Conclusion: Our study suggests that a low level of plasma PLP is associated with symptoms of depression. Randomized trials are now justified and needed in order to examine whether treatment with vitamin B6 may improve symptoms of depression.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Regular Article

Published online: October 15, 2004
Issue release date: November – December

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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