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Table of Contents
Vol. 102, No. 3, 2004
Issue release date: September 2004
Section title: Clinical Cardiology
Cardiology 2004;102:166–170
(DOI:10.1159/000080486)

Effect of Withdrawal of Statin on C-Reactive Protein

Lee K.-T.a · Lai W.-T.a · Chu C.-S.a · Tsai L.-Y.b · Yen H.-W.a · Voon W.-C.a · Sheu S.-H.a
aSection of Cardiology, Department of Internal Medicine and bDepartment ofClinical Chemistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Cardiology

Received: August 11, 2003
Accepted: January 17, 2004
Published online: September 29, 2004
Issue release date: September 2004

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Background: C-reactive protein is considered a risk factor for coronary artery disease. In addition to its lipid-lowering properties, statin decreases the level of C-reactive protein. Abrupt cessation of statin therapy during treatment could increase the incidence of cardiac events in patients with atherosclerotic heart disease. The changes of C-reactive protein after withdrawal of statin therapy are still unknown. Methods: Twenty patients with hyperlipidemia received statin (atorvastatin, 10 mg/day) therapy for 3 months. The levels of lipid profiles and C-reactive protein were assessed before receiving the statin therapy, immediately after 3 months of therapy, and on the 3 consecutive days after withdrawal of statin treatment. Results: After 3 months of statin therapy, the total cholesterol, low-density lipoprotein cholesterol (LDL-chol), and C-reactive protein were significantly reduced (264.94 ± 16.23 vs. 183.44 ± 16.34 mg/dl, 183.17 ± 34.56 vs. 122.00 ± 17.66 mg/dl, and 2,309.00 ± 437.85 vs. 1,257.95 ± 207.99 ng/ml, respectively). The level of C-reactive protein increased on the second day after withdrawal of statin therapy (2,590.14 ± 1,045.05 vs. 1,257.95 ± 207.99 ng/ml); however, the total cholesterol and LDL-chol did not increase during the 3-day period after withdrawal of statin therapy. Conclusions: The increase in the level of C-reactive protein after withdrawal of statin therapy may be a contributing factor to the increased incidence of cardiac events in patients who have abruptly stopped statin therapy.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Cardiology

Received: August 11, 2003
Accepted: January 17, 2004
Published online: September 29, 2004
Issue release date: September 2004

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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