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Vol. 62, Suppl. 1, 2004
Issue release date: February 2005
Section title: Efficacy
Horm Res 2004;62(suppl 1):37–43
(DOI:10.1159/000080757)

Insulin-Like Growth Factor (IGF) Parameters and Tools for Efficacy: The IGF-I Generation Test in Children

Rosenfeld R.G.a,b,c · Buckway C.c · Selva K.c · Pratt K.L.c · Guevara-Aguirre J.d
aLucile Packard Foundation for Children’s Health, Palo Alto; bStanford University, Stanford, Calif.; cOregon Health and Science University, Portland, Oreg., USA; dInstitute of Endocrinology, Metabolism, and Reproduction IEMIR, Quito, Ecuador

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Article / Publication Details

First-Page Preview
Abstract of Efficacy

Published online: 3/10/2005
Issue release date: February 2005

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Serum levels of growth hormone (GH)-dependent peptides could provide important and valuable measures of GH sensitivity and, potentially, responsiveness. In normal individuals, serum insulin-like growth factor I (IGF-I) concentrations are dependent on the dose of GH given, with IGF-I responsiveness not decreasing with age. Individuals heterozygous for the E180 GH receptor (GHR) splice mutation have normal IGF-I generation, but those homozygous for the E180 splice mutation have very low basal and stimulated IGF-I concentrations. Similar results are observed for the serum IGF-binding protein 3 (IGFBP-3) response to GH, with a correlation between changes in serum concentrations of IGF-I and changes in IGFBP-3 in normal, heterozygotic, GH-insensitive and GH-deficient participants. In individuals with the E180 splice mutation, IGF-I and IGFBP-3 tests show sensitivity and specificity for detecting GH insensitivity (GHI). In children with idiopathic short stature, it appears that some individuals have selective resistance to GH, with their ability to generate IGF-I more impaired than their ability to generate other GH-dependent peptides. This heterogeneous group may require individualization of GH dosage. IGF generation tests remain the best short-term, in vivo test for classic GHI, although diagnostic tests will undoubtedly require further modification to identify milder pathophysiologic abnormalities.

© 2004 S. Karger AG, Basel


  

Author Contacts

Prof. R.G. Rosenfeld, Senior Vice-President for Medical Affairs
Lucile Packard Foundation for Children’s Health
770 Welch Road, Suite 350
Palo Alto, CA 94022 (USA)
Tel. +1 650 724 6930, Fax +1 650 498 2619, E-Mail ron.rosenfeld@lpfch.org

  

Article Information

Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 2, Number of References : 26

  

Publication Details

Hormone Research (From Development Endocrinology to Clinical Research)

Vol. 62, No. Suppl. 1, Year 2004 (Cover Date: Released February 2005)

Journal Editor: P. Czernichow, Paris
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/hre


Article / Publication Details

First-Page Preview
Abstract of Efficacy

Published online: 3/10/2005
Issue release date: February 2005

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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