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Table of Contents
Vol. 62, Suppl. 1, 2004
Issue release date: February 2005
Section title: Safety
Horm Res 2004;62(suppl 1):101–107
(DOI:10.1159/000080767)

Insulin-Like Growth Factor I and Impaired Glucose Tolerance

Dunger D.B. · Yuen K. · Ong K.
University Department of Paediatrics, University of Cambridge, Cambridge, UK

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Article / Publication Details

First-Page Preview
Abstract of Safety

Published online: March 10, 2005
Issue release date: February 2005

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

The effects of circulating insulin-like growth factor I (IGF-I) on glucose metabolism are well recognized. IGF-I is also important in maintaining β-cell mass and regulating endogenous growth hormone (GH) levels. Low IGF-I levels could explain links between small birth size and the risk of developing type 2 diabetes mellitus in short, obese adults. In a recent prospective study, childhood insulin secretion was related to IGF-I levels and statural growth, whereas insulin sensitivity was related to early post-natal weight gain. Common genetic polymorphisms in the IGF1 gene have been linked to small birth size, post-natal growth and future diabetes risk, but these results have been inconsistent. Recent adult studies have demonstrated that lower baseline IGF-I levels predict the subsequent development of impaired glucose tolerance (IGT), type 2 diabetes and cardiovascular disease. Administration of low-dose GH therapy, at a dose that minimizes the lipolytic effects of GH and has the ability to increase IGF-I levels, enhances insulin sensitivity in young healthy adults and in GH-deficient adults and increases insulin secretion in individuals with IGT. Whether the administration of low-dose GH, recombinant IGF-I or combined IGF-I/IGF-binding protein 3 therapy prevents future development of IGT or type 2 diabetes in high-risk normoglycaemic and GH-deficient individuals merits further long-term studies.

© 2004 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Safety

Published online: March 10, 2005
Issue release date: February 2005

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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