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Vol. 209, No. 4, 2004
Issue release date: 2004
Section title: Pharmacology and Treatment
Dermatology 2004;209:314–320
(DOI:10.1159/000080855)

Influence of Pimecrolimus Cream 1% on Different Morphological Signs of Eczema in Infants with Atopic Dermatitis

Breuer K.a · Braeutigam M.b · Kapp A.a · Werfel T.a
aDepartment of Dermatology and Allergology, Hannover Medical University, Hannover, and bNovartis Pharma GmbH, Clinical Research, Nürnberg, Germany

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: 7/1/2004
Accepted: 7/2/2004
Published online: 12/4/2004
Issue release date: 2004

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: In the published studies on the efficacy of the topical immunomodulator pimecrolimus, different eczema scores were used, and the impact on morphological key signs of eczema was not analysed. Objective: To compare the influence of pimecrolimus cream 1% on different standard eczema scores in infants with atopic dermatitis and to analyse the impact of treatment on the individual morphological key signs of eczema. Methods: Pimecrolimus cream 1% (n = 129) or double-blind vehicle control (n = 66) was administered for 4 weeks. The Eczema Area and Severity Index (EASI), Investigators’ Global Assessment (IGA) and Scoring Atopic Dermatitis Index (SCORAD) were determined and were correlated with each other. Results: Following treatment with pimecrolimus, the EASI, IGA and SCORAD were significantly reduced on day 29 as compared with the vehicle group (p < 0.001, p < 0.001, p = 0.002, respectively). There was a close correlation between EASI, IGA and SCORAD. The single parameters of the EASI were already significantly decreased by day 4 in the pimecrolimus group as compared to vehicle (each p < 0.001). Conclusion: Treatment with pimecrolimus 1% cream leads to a rapid improvement of all morphological signs of eczema. The close correlation of different scores was shown for the first time.

© 2004 S. Karger AG, Basel


  

Author Contacts

Kristine Breuer
Hannover Medical University
Department of Dermatology and Allergology
Ricklinger Strasse 5, DE–30449 Hannover (Germany)
Tel. +49 511 9246 330, Fax +49 511 9246 440, E-Mail breuer.kristine@mh-hannover.de

  

Article Information

Received: July 1, 2004
Accepted: July 2, 2004
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 5, Number of References : 31

  

Publication Details

Dermatology (International Journal for Clinical and Investigative Dermatology)

Vol. 209, No. 4, Year 2004 (Cover Date: 2004)

Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/drm


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: 7/1/2004
Accepted: 7/2/2004
Published online: 12/4/2004
Issue release date: 2004

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 5

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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