Journal Mobile Options
Table of Contents
Vol. 50, No. 4, 2004
Issue release date: November 2004
Section title: Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2004;50:296–300
(DOI:10.1159/000080956)

Reduced White Matter Volume of the Caudate Nucleus in Patients with Schizophrenia

Takase K. · Tamagaki C. · Okugawa G. · Nobuhara K. · Minami T. · Sugimoto T. · Sawada S. · Kinoshita T.
Departments of aNeuropsychiatry and bRadiology, Kansai Medical University, Osaka, Japan

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 11/5/2004

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

To examine volumetric abnormality, the caudate nucleus was measured in patients with schizophrenia and healthy subjects using magnetic resonance imaging. The absolute and relative volumes of white matter in the caudate nucleus were found to be significantly smaller in patients with schizophrenia compared to those in healthy subjects. There were significant correlations between dosages of neuroleptics during the previous year and absolute gray matter volumes of the caudate nucleus as well as relative white matter volumes in patients with schizophrenia. These findings suggest that reduced white matter volume of the caudate nucleus may be a factor affecting the abnormal connectivity of the corticostriatal loop, and that neuroleptic medication would be related to white matter alteration in patients with schizophrenia. Our result replicates a previous study reporting that there is a lack of negative correlation between age and caudate nucleus volume. We also suggest that the disease process of schizophrenia might interfere with normal aging.


  

Author Contacts

Katsunori Takase, MD
Department of Neuropsychiatry, Kansai Medical University
10–15 Fumizonocho Moriguchi
Osaka 570-8506 (Japan)
Tel. +81 6 6992 1001, Fax +81 6 6995 2669, E-Mail takasek@takii.kmu.ac.jp

  

Article Information

Number of Print Pages : 5
Number of Figures : 5, Number of Tables : 2, Number of References : 20

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 50, No. 4, Year 2004 (Cover Date: Released November 2004)

Journal Editor: J. Mendlewicz, Brussels; B. Saletu, Vienna; P. Netter, Giessen; T. Kinoshita, Osaka
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/nps


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 11/5/2004

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.