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Table of Contents
Vol. 43, No. 1, 2000
Issue release date: January 2000
Section title: Original Paper
Eur Neurol 2000;43:23–29
(DOI:10.1159/000008124)

Preclinical Impairment of the Striatal Dopamine Transporter System in Sporadic Olivopontocerebellar Atrophy: Studied with [123I]β-CIT and SPECT

Kim G.M.a · Kim S.E.b · Lee W.Y.a
Departments of aNeurology and bNuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 12, 2000
Issue release date: January 2000

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

We investigated whether the dopamine (DA) transporter system is impaired in sporadic olivopontocerebellar atrophy (sOPCA) patients without clinical parkinsonism using the DA transporter radiotracer [123I]β-CIT [2β-carboxymethoxy-3β-(4-iodophenyl)tropane] and single-photon emission computed tomography (SPECT). SPECT scans were acquired in 9 patients with sOPCA, 7 multiple system atrophy (MSA) patients with parkinsonism (MSA-P), and 7 age-matched healthy controls 20–24 h after the intravenous injection of [123I]β-CIT. [123I]β-CIT-specific binding in the striatum was determined as the radioactivity ratio of the striatum to the occipital cortex (specific binding ratio, SBR). In patients with sOPCA and MSA-P, SBRs in the right and left striatum and the mean SBR were significantly lower than those in controls (p < 0.05). The mean SBRs in patients with sOPCA and MSA-P were reduced to 69.0 and 60.7% of the control mean, respectively. However, there was no significant difference in SBRs between sOPCA and MSA-P patients. In sOPCA patients, the mean SBR was significantly correlated with the score of the clinical cerebellar function scale (r = –0.670, p = 0.024). These results indicate that even in the absence of clinical parkinsonism, the striatal dopaminergic system may be impaired in sOPCA. The DA transporter loss in sOPCA serves as another clue for sOPCA being a part of the spectrum of MSA.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 12, 2000
Issue release date: January 2000

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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