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Vol. 112, No. 4, 2004
Issue release date: November 2004
Section title: Original Paper
Acta Haematol 2004;112:203–208
(DOI:10.1159/000081273)

Primary Salivary Gland Lymphoma: A Clinicopathologic Study of 23 Cases in Taiwan

Dunn P. · Kuo T.-t. · Shih L.-Y. · Lin T.-L. · Wang P.-N. · Kuo M.-C. · Tang C.-C.
aDivision of Hematology-Oncology, Department of Internal Medicine, bDepartment of Pathology, Chang Gung Memorial Hospital and cSchool of Medicine, Chang Gung University, Taipei, Taiwan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/27/2003
Accepted: 4/29/2004
Published online: 11/25/2004

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Twenty-three patients with primary salivary gland lymphoma were diagnosed between 1990 and 2001. The sites of involvement were the parotid gland in 13, the submandibular gland in 9 and the minor salivary gland in 1. The sites of lymphoma involvement beyond the salivary glands were the cervical lymph nodes in 7, bone marrow in 3, the axillary lymph nodes in 3, the nasopharynx in 2, the abdominal lymph nodes in 2, the palate, the subconjunctiva, and the spleen in 1 each patient. Histologically, 19 patients had lymphomas of mucosa-associated lymphoid tissue (MALT) with myoepithelial sialadenitis in 13, 3 patients had diffuse large cell lymphomas and 1 had follicular lymphoma. Six patients were in stage I, 4 in II, 1 in III and 12 in IV. Eight of 23 patients (35%) had autoimmune diseases before or after the diagnosis of NHL and all suffered from MALT lymphoma. Four patients with parotid MALT lymphoma had primary or secondary Sjögren’s syndrome. One each patient suffered from hyperthyroidism, systemic lupus erythematosus, membranoproliferative glomerulonephritis and cryoglobulinemia, respectively. All the 6 stage I patients had achieved complete remission (CR) without relapses 17–84 months (median 44 months) after treatment. Excluding a stage IV patient with follicular lymphoma who died at 3.5 months without treatment, CR was achieved in all of the remaining 16 patients. However, a high relapse rate (9/16, 56%) was noted in stage II–IV patients. These patients tended to relapse in the original sites, but achieved CR again after chemotherapy or radiotherapy. One patient with MALT lymphoma developed histologic transformation into diffuse large lymphoma during relapse and died of refractory disease. Overall, only 2 patients succumbed. The overall survival and relapse-free survival rates at 5 years were 94.7 and 51.4%, respectively. Thus, salivary gland lymphoma proved to be an indolent disease.


  

Author Contacts

Dr. Dunn Po
Division of Hematology-Oncology, Department of Internal Medicine
Chang Gung Memorial Hospital, 199 Tung Hwa North Road
Taipei 105 (Taiwan)
Tel. +886 3 3281200, ext. 2524, Fax +886 3 3286697, E-Mail dunnpo@adm.cgmh.org.tw

  

Article Information

Received: November 27, 2003
Accepted after revision: March 29, 2004
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 1, Number of References : 32

  

Publication Details

Acta Haematologica

Vol. 112, No. 4, Year 2004 (Cover Date: Released November 2004)

Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)

For additional information: http://www.karger.com/aha


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/27/2003
Accepted: 4/29/2004
Published online: 11/25/2004

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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