We examine the current effort to develop a haplotype map of the human genome and suggest an alternative approach which represents linkage disequilibrium patterns in the form of a metric LD map. LD maps have some of the useful properties of genetic linkage maps but have a much higher resolution which is optimal for SNP-based association mapping of common diseases. The studies that have been undertaken to date suggest that LD and recombination maps show some close similarities because of abundant, narrow, recombination hot spots. These hot spots are co-localised in all populations but, unlike linkage maps, LD maps differ in scale for different populations because of differences in population history. The prospects for developing optimized panels of SNPs and the use of linkage disequilibrium maps in disease gene localisation are assessed in the light of recent evidence.
© 2004 S. Karger AG, Basel
Human Genetics, School of Medicine
University of Southampton
Southampton SO16 6YD (UK)
Tel. +44 23 80 796939, Fax +44 23 80 794264, E-Mail firstname.lastname@example.org
Received: April 23, 2004
Accepted after revision: June 22, 2004
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 0, Number of References : 45
Human Heredity (International Journal of Human and Medical Genetics)
Vol. 58, No. 1, Year 2004 (Cover Date: Released December 2004)
Journal Editor: J. Ott, New York, N.Y.
ISSN: 0001–5652 (print), 1423–0062 (Online)
For additional information: http://www.karger.ch/hhe
Article / Publication Details
Published online: 12/13/2004
Issue release date: December 2004
Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 0
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: http://www.karger.com/HHE
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