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Vol. 48, No. 2-3, 2005
Issue release date: March–June 2005
Section title: Original Paper
Intervirology 2005;48:112–119
(DOI:10.1159/000081737)

Infectious Source Factors Affecting the Severity of Sexually Transmitted Acute Hepatitis due to Hepatitis B Virus Genotype C

Michitaka K.a · Horiike N.b · Chen Y.b · Yatsuhashi H.g · Yano M.f · Kojima N.c · Ohkubo K.c · Tanaka Y.d · Yamamoto K.e · Ohno N.f · Onji M.b
aEndoscopy Center and bThird Department of Internal Medicine, Ehime University School of Medicine, cInternal Medicine, Ohzu Central Hospital, dInternal Medicine, Ehime Prefectural Central Hospital, eDepartment of Gastroenterology, Matsuyama Shimin Hospital, and fOhno Naika, Ehime, and gClinical Research Center, National Nagasaki Medical Center, Nagasaki, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/15/2004
Accepted: 5/5/2004
Published online: 3/24/2005
Issue release date: March–June 2005

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Objective: The aim of this study was to identify clinical features and virological aspects of infectious sources that are related to the severity of sexually transmitted acute hepatitis B virus (HBV) infection in patients, especially in cases of genotype C. Methods: Nineteen patients with acute HBV infection, 10 classified with severe acute hepatitis (SH) (prothrombin time; PT <40%) and 9 with typical acute hepatitis (AH) (PT >40%), and their infectious sources (all were sexual partners) were studied. Infectious source factors were analyzed in relation to the severity of hepatitis in the patients’ partners. Results: The nucleotide homology of HBV-DNA between each pair was ≧98.9%. Sixteen were infected with HBV genotype C. Among the 16 infectious sources, age, numbers with elevated alanine aminotransferase (ALT, 7/9 vs. 1/7), anti-HBe positivity (8/9 vs. 1/7) and core promoter mutations at nt 1762 (7/9 vs. 1/7), nt 1764 (8/9 vs. 1/7) and precore mutation at nt 1896 (8/9 vs. 1/7) were significantly higher in the sources of SH than in those of AH. Conclusion: Higher age, elevated ALT, anti-HBe positivity and core promoter/precore mutations were possible risk factors for an infectious source of the severe form of sexually transmitted acute hepatitis due to HBV genotype C.

© 2005 S. Karger AG, Basel


  

Author Contacts

Morikazu Onji, MD
Third Department of Internal Medicine, Ehime University School of Medicine
Shigenobu-cho, Onsen-gun
Ehime-ken, 791-0295 (Japan)
Tel. +81 89 960 5308, Fax +81 89 960 5310, E-Mail onjimori@m.ehime-u.ac.jp

  

Article Information

Received: March 15, 2004
Accepted: May 5, 2004
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 3, Number of References : 49

  

Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 48, No. 2-3, Year 2005 (Cover Date: March-June 2005)

Journal Editor: U.G. Liebert, Leipzig
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/int


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/15/2004
Accepted: 5/5/2004
Published online: 3/24/2005
Issue release date: March–June 2005

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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