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Table of Contents
Vol. 48, No. 2-3, 2005
Issue release date: March – June
Section title: Short Communication
Intervirology 2005;48:201–206
(DOI:10.1159/000081749)

Analysis of Human Cytomegalovirus UL144 Variability in Low-Passage Clinical Isolates in Japan

Murayama T.a · Takegoshi M.c · Tanuma J.b · Eizuru Y.a
aDivision of Persistent and Oncogenic Viruses, Center for Chronic Viral Disease, bDepartments of Oral Pathology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, and cMolecular Biology, School of Medicine, Tookai University, Kanagawa, Japan

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: February 09, 2004
Accepted: May 24, 2004
Published online: March 24, 2005
Issue release date: March – June

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor-like receptor gene and the UL55 envelope glycoprotein B gene from 42 patients with congenital human cytomegalovirus (HCMV) infection or other diseases were sequenced. Of the 42 patients, 16 (38%) had UL144 group 1 [group 1A, 15 of 16 (94%); group 1B, 1 of 16 (6%); group 1C, 0 of 16 (0%)], 5 patients (12%) had UL144 group 2, and 21 patients (50%) had UL144 group 3. Although group 1C was not found in Japan strains (0%), it was found in USA strains (22%). Other HCMV polymorphisms should be further evaluated for their potential relevance to neonatal infection, and acquired immunodeficiency syndrome-associated HCMV diseases.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: February 09, 2004
Accepted: May 24, 2004
Published online: March 24, 2005
Issue release date: March – June

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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