The value of an early initial coadministration of levodopa (L-dopa) and lisuride in Parkinson’s disease was the main goal of the present study. Eighty-two patients with recently diagnosed idiopathic Parkinson’s disease were randomized into two groups for treatment with L-dopa alone or L-dopa + lisuride. The trial was double-blinded for the first year and open for the following 4 years. Selegiline (10 mg/day b.i.d.) was added in both groups at the end of the first year. Outcome measures were evolution of L-dopa dosage and Unified Parkinson’s Disease Rating Scale scores and subscores, and incidence of motor complications. The dropout rate was higher in the L-dopa group (63.4%) than in the combination group. Motor improvement was better (p < 0.01) in the L-dopa + lisuride group. Expected motor complications were rare, moderate and equivalent in the two groups despite a difference in L-dopa dosage (446.7 vs. 387.5 mg/day). Long-term follow-up demonstrated the L-dopa-sparing effect of lisuride (average 1 mg/day), the beneficial effect of early combination therapy on motor status and the paucity of motor complications in both groups.
© 2000 S. Karger AG, Basel
H. Allain, MD
Laboratoire de Pharmacologie Expérimentale et Clinique et Service de Neurologie
Faculté de Médecine, Université de Rennes I
2, Avenue du Pr. Léon Bernard, F–35043 Rennes Cedex (France)
Tel. +33 2 99 33 68 72, Fax +33 2 99 33 68 90, E-Mail Herve.Allain@univ-rennes1.fr
Received: Received: April 20, 1999
Accepted: December 2, 1999
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 2, Number of References : 37
Founded 1897 as ‘Monatsschrift für Psychiatrie und Neurologie’
Vol. 44, No. 1, Year 2000 (Cover Date: Released July 2000)
Journal Editor: J. Bogousslavsky, Lausanne
ISSN: 0014–3022 (print), 1421–9913 (Online)
For additional information: http://www.karger.com/journals/ene
Article / Publication Details
Published online: 7/7/2000
Issue release date: July 2000
Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: http://www.karger.com/ENE
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