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Vol. 44, No. 1, 2000
Issue release date: July 2000
Section title: Original Paper
Eur Neurol 2000;44:22–30
(DOI:10.1159/000008188)

Five-Year Follow-Up of Early Lisuride and Levodopa Combination Therapy versus Levodopa Monotherapy in de novo Parkinson’s Disease

Allain H. · Destée A. · Petit H. · Patay M. · Schück S. · Bentué-Ferrer D. · Le Cavorzin P.
aLaboratoire de Pharmacologie Expérimentale et Clinique et Service de Neurologie, Faculté de Médecine, Université de Rennes I, Rennes, bClinique Neurologique, Hôpital Roger Salengro, Lille, and cLaboratoire Schering S.A., Lys-Les-Lannoy, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/7/2000

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

The value of an early initial coadministration of levodopa (L-dopa) and lisuride in Parkinson’s disease was the main goal of the present study. Eighty-two patients with recently diagnosed idiopathic Parkinson’s disease were randomized into two groups for treatment with L-dopa alone or L-dopa + lisuride. The trial was double-blinded for the first year and open for the following 4 years. Selegiline (10 mg/day b.i.d.) was added in both groups at the end of the first year. Outcome measures were evolution of L-dopa dosage and Unified Parkinson’s Disease Rating Scale scores and subscores, and incidence of motor complications. The dropout rate was higher in the L-dopa group (63.4%) than in the combination group. Motor improvement was better (p < 0.01) in the L-dopa + lisuride group. Expected motor complications were rare, moderate and equivalent in the two groups despite a difference in L-dopa dosage (446.7 vs. 387.5 mg/day). Long-term follow-up demonstrated the L-dopa-sparing effect of lisuride (average 1 mg/day), the beneficial effect of early combination therapy on motor status and the paucity of motor complications in both groups.


  

Author Contacts

H. Allain, MD
Laboratoire de Pharmacologie Expérimentale et Clinique et Service de Neurologie
Faculté de Médecine, Université de Rennes I
2, Avenue du Pr. Léon Bernard, F–35043 Rennes Cedex (France)
Tel. +33 2 99 33 68 72, Fax +33 2 99 33 68 90, E-Mail Herve.Allain@univ-rennes1.fr

  

Article Information

Received: Received: April 20, 1999
Accepted: December 2, 1999
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 2, Number of References : 37

  

Publication Details

European Neurology
Founded 1897 as ‘Monatsschrift für Psychiatrie und Neurologie’

Vol. 44, No. 1, Year 2000 (Cover Date: Released July 2000)

Journal Editor: J. Bogousslavsky, Lausanne
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/journals/ene


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/7/2000

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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