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Table of Contents
Vol. 66, No. 6, 2004
Issue release date: 2004
Section title: Original Paper
ORL 2004;66:325–331
(DOI:10.1159/000081890)

A Long-Term Follow-Up Study after Split-Course Irradiation with Concurrent Chemotherapy (Carboplatin) for Locally Advanced Head and Neck Cancer and a Review of the Literature

Pradier O.a · Christiansen H.a · Ambrosch P.b · Kron M.c · Schmidberger H.a · Hess C.F.a
Departments of aRadiotherapy and bOtorhinolaryngology, University of Göttingen, Göttingen, and cDepartment of Biometry and Medical Documentation, Ulm, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/27/2004
Accepted: 9/9/2004
Published online: 1/25/2005
Issue release date: 2004

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Background: Radiotherapy is often the primary treatment for advanced head and neck cancer, but the rates of locoregional recurrence are high and survival is poor. The purpose of this study was to evaluate the efficacy and toxicity of split-course radiotherapy combined with concurrent carboplatin chemotherapy after long-term follow-up. Patients and Methods: From August 1987 to May 1994, 66 patients (54 males, 12 females, mean age 58 years) with advanced inoperable oropharynx cancer were treated at the University of Göttingen, Göttingen, Germany. Tumour localization in the oropharynx was: tonsil (n = 33), base of tongue (n = 28), soft palate (n = 2) and posterior pharyngeal wall (n = 3). Forty-nine patients presented with a T4 tumour, 15 were T3 and 2 were T2. The nodal status was distributed as follows: N0 (n = 7), N1 (n = 5), N2 (n = 28) and N3 (n = 26). A total radiation dose of 5,670 cGy was applied in 6 weeks as a split-course regimen (2 × 2.1 Gy/day, 4 times a week, weeks 1 and 2 and weeks 5 and 6). Concomitant carboplatin chemotherapy was given each radiotherapy day before irradiation (50 mg/m2). Results: In December 2003, 12 patients were still alive. Survivors have reached a maximum follow-up of 170.5 months (median 14.3 months). Two- and 5-year overall survival was 32 and 18%, 2-year disease-free survival 27%. Therapy was tolerated moderately (19% grade 3 skin reaction, 26% grade 3 mucositis, 23% grade 3 xerostomia, 20% grade 3 leucopenia, 8% grade 3 thrombopenia and 25% grade 3 anaemia). Conclusion: Split-course radiotherapy and concomitant carboplatin chemotherapy can be carried out in inoperable head and neck cancer without severe toxicity. After long-term follow-up, survival rates are unfavourable in this poor prognostic group of patients.

© 2004 S. Karger AG, Basel


  

Author Contacts

Olivier Pradier, MD
Department of Radiotherapy, University of Göttingen
Robert Koch-Strasse 40
DE–37075 Göttingen (Germany)
Tel. +49 551 398866, Fax +49 551 3912614, E-Mail opradie@gwdg.de

  

Article Information

Received: May 27, 2004
Accepted after revision: September 9, 2004
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 3, Number of References : 46

  

Publication Details

ORL (Journal for Oto-Rhino-Laryngology and Its Related Specialties)

Vol. 66, No. 6, Year 2004 (Cover Date: 2004)

Journal Editor: B.W. O’Malley, Jr., Philadelphia, Pa.
ISSN: 0301–1569 (print), 1423–0275 (Online)

For additional information: http://www.karger.com/orl


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/27/2004
Accepted: 9/9/2004
Published online: 1/25/2005
Issue release date: 2004

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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