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Vol. 40, No. 4, 2004
Issue release date: July–August 2004
Section title: Case Report
Pediatr Neurosurg 2004;40:171–181
(DOI:10.1159/000081935)

Anaplastic Pleomorphic Xanthoastrocytomas

Review of the Literature with Reference to Malignancy Potential

Tekkök İ.H. · Sav A.
aMersin University School of Medicine, Mersin, and bMarmara University School of Medicine, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 5/6/2004
Accepted: 9/15/2004
Published online: 12/15/2004
Issue release date: July–August 2004

Number of Print Pages: 11
Number of Figures: 7
Number of Tables: 2

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: http://www.karger.com/PNE

Abstract

Malignancy potential of pleomorphic xanthoastrocytomas (PXAs) has rather been an underestimated reality. We report the case of a 13-year-old boy who presented with signs of increased intracranial pressure. The child had been epileptic since the age of 2. Computed tomography and magnetic resonance scans revealed a huge left frontal mass. At surgery, a subtotal excision was accomplished. Histopathological diagnosis was anaplastic PXA (grade III; WHO, 2000). The tumor showed an increased mitotic index and minimal endothelial proliferation. The patient died 3.5 months later due to a fatal intracranial hemorrhage. A review of the entire PXA literature revealed 15 well-documented cases of PXA with subsequent malignant transformation and 11 cases of primary anaplastic PXA. The prognosis was grim for both subsets of patients. Anaplastic PXAs clearly represent the transition between the original PXA concept and lipidized giant-cell glioblastoma.


  

Author Contacts

Prof. Dr. İsmail H. Tekkök
Beyin ve Sinir Cerrahisi Departmanı
Mersin Universitesi Tıp Fakültesi
TR–33079 Mersin (Turkey)
Tel. +90 533 241 2780, Fax +90 324 336 7365, E-Mail tekkokih@mersin.edu.tr

  

Article Information

Received: May 6, 2004
Accepted after revision: September 15, 2004
Number of Print Pages : 11
Number of Figures : 7, Number of Tables : 2, Number of References : 45

  

Publication Details

Pediatric Neurosurgery

Vol. 40, No. 4, Year 2004 (Cover Date: July-August 2004)

Journal Editor: D.M. Frim, Chicago, Ill.
ISSN: 1016–2291 (print), 1423–0305 (Online)

For additional information: http://www.karger.com/pne


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 5/6/2004
Accepted: 9/15/2004
Published online: 12/15/2004
Issue release date: July–August 2004

Number of Print Pages: 11
Number of Figures: 7
Number of Tables: 2

ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)

For additional information: http://www.karger.com/PNE


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