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Vol. 135, No. 4, 2004
Issue release date: December 2004
Section title: Original Paper
Int Arch Allergy Immunol 2004;135:336–342
(DOI:10.1159/000082329)

The Allergic March in Pollinosis: Natural History and Therapeutic Implications

Marogna M.a · Falagiani P.b · Bruno M.b · Massolo A.c · Riva G.b
aPneumology Unit, Cuasso al Monte, Macchi Hospital Foundation, Varese; bMedical Department, Lofarma SpA, Milan, and cSection of Behavioral Ecology, Ethology and Wildlife Management, Department of Environmental Sciences, Siena University, Siena, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/25/2004
Accepted: 8/3/2004
Published online: 12/20/2004
Issue release date: December 2004

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: That specific immunotherapy (SIT) can slow the march of allergy has been confirmed in controlled clinical trials. However, an assessment of its effects in everyday life, in a large cohort of patients, might provide further useful information. Methods: This observational study comprised 3,643 patients allergic to pollens; 1,620 with pure allergic rhinitis or rhinitis and intermittent or mild-persistent bronchial asthma, responding poorly to standard pharmacological therapy (SPT), were treated for 3 years with SPT alone (pure rhinitis, n = 890), or combined with continuous SIT (rhinitis and asthma, n = 730). Symptom/drug scores were recorded, respiratory function and skin tests were done, and methacholine challenge was scheduled at the beginning and end of the study. A series of 2,023 patients with pure rhinitis, responsive to SPT, were asked to ‘self-medicate’ as needed, serving as a control group to check the incidence of asthma. Results: The incidence of rhinitis-asthma co-morbidity was highest in the self-medication group (50.8%). Persistent rhinitis was associated with asthma more often than the intermittent form, regardless of the severity of the symptoms that led to progression to asthma in patients with intermittent rhinitis. Treatment with SIT combined with SPT always slowed the allergic march which, however, was not influenced by drugs alone. Conclusions: In routine clinical practice, SIT is effective in preventing the allergic march. Patients with persistent rhinitis, who are at greatest risk of progression to asthma, appear to be the most logical candidates.

© 2004 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Maurizio Marogna, MD
Pneumology Unit, Cuasso al Monte
Macchi Hospital Foundation, via Imborgnana 7
IT–21050 Cuasso al Monte, Varese (Italy)
Tel. +39 0332 910203, Fax +39 0332 917323, E-Mail maurizio_marogna@libero.it

  

Article Information

Received: February 25, 2004
Accepted after revision: August 3, 2004
Published online: November 24, 2004
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 3, Number of References : 41

  

Publication Details

International Archives of Allergy and Immunology

Vol. 135, No. 4, Year 2004 (Cover Date: December 2004)

Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information: http://www.karger.com/iaa


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/25/2004
Accepted: 8/3/2004
Published online: 12/20/2004
Issue release date: December 2004

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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