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Vol. 12, No. 1, 2005
Issue release date: March 2005
Section title: Original Paper
Neuroimmunomodulation 2005;12:54–59
(DOI:10.1159/000082364)

ICAM G241A Polymorphism and Soluble ICAM-1 Serum Levels: Evidence for an Active Immune Process in Schizophrenia

Krönig H. · Riedel M. · Schwarz M.J. · Strassnig M. · Möller H.-J. · Ackenheil M. · Müller N.
Psychiatric Hospital, Ludwig-Maximilian University Munich, Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/10/2002
Accepted: 3/23/2004
Published online: 3/7/2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM

Abstract

Objectives: We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism (SNP) of the ICAM-1 gene was described at position 241. The G→A SNP results in a nonsynonymous amino acid exchange of the ICAM-1 protein, and the A allele was shown to be also associated with several immunological disorders like rheumatoid arthritis. Methods: We investigated 70 schizophrenic patients and 128 unrelated healthy control persons regarding the relationship between the serum levels of sICAM-1 and the ICAM-1 G214A polymorphism. Results: We were able to replicate our previous finding of reduced sICAM-1 levels in schizophrenia. Healthy control persons carrying the polymorphic A allele showed markedly lower sICAM-1 serum levels than carriers of the homozygous GG wild type (p < 0.004). In contrast, no significant difference in the sICAM-1 serum levels were seen regarding the G241A genotype distribution in schizophrenic patients. Conclusion: We hypothesize that the biochemical effect of the G241A SNP is masked in schizophrenic patients, indicating a disease-related mechanism leading to reduced levels of sICAM-1 in schizophrenia.


  

Author Contacts

Markus J. Schwarz, MD
Psychiatric Hospital, Ludwig Maximilian University Munich
Nussbaumstrasse 7, DE–80336 Munich (Germany)
Tel. +49 89 5160 2761, Fax +49 89 5160 4741
E-Mail Markus.Schwarz@med.uni-muenchen.de

  

Article Information

Received: October 3, 2002
Accepted: March 23, 2004
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 45

  

Publication Details

Neuroimmunomodulation

Vol. 12, No. 1, Year 2005 (Cover Date: Released March 2005)

Journal Editor: Chrousos, G.P. (Bethesda, Md.)
ISSN: 1021–7401 (print), 1423–0216 (Online)

For additional information: http://www.karger.com/nim


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/10/2002
Accepted: 3/23/2004
Published online: 3/7/2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: http://www.karger.com/NIM


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