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Vol. 87, No. 3, 2005
Issue release date: April 2005
Section title: Original Paper
Biol Neonate 2005;87:160–163
(DOI:10.1159/000082367)

Hydrolysis of Casein Accelerates Gastrointestinal Transit via Reduction of Opioid Receptor Agonists Released from Casein in Rats

Mihatsch W.A.a · Franz A.R.a · Kuhnt B.b · Högel J.c · Pohlandt F.a
aDepartment of Pediatrics, bLaboratory Animals Research Unit and cDepartment of Biometry and Medical Documentation, Ulm University, Ulm, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2004
Accepted: 9/20/2004
Published online: 4/6/2005
Issue release date: April 2005

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Protein hydrolysate accelerates gastrointestinal transit (GIT) and feeding advancement in preterm infants compared to native protein. In rat pups, opioid receptor agonists released from casein during digestion such as β-casomorphins slow down GIT. We hypothesized that hydrolysis of casein reduces the opioid activity released during digestion thereby accelerating GIT compared to native casein. Objective: The aim of the present study was to investigate whether casein hydrolysate accelerates GIT compared to native casein and whether pretreatment with naloxone, an opioid receptor blocker, abolishes this difference in rat pups. Methods: In a randomized controlled trial following a 2 × 2 factorial design, 216 female Wistar rat pups were fed with pellets based on hydrolyzed or native casein. After pretreatment with naloxone or normal saline, carmine red was administered by oro-gastric gavage as a tracer for GIT velocity measurement. Four hours later the animals were sacrificed, their intestine was removed and the length of the colon from the cecocolonic junction to the anus was measured. GIT was recorded as percentage of the total colonic length (percentage of colonic transit) passed by carmine red. Data were given as mean ± SD. Results: GIT was significantly higher with hydrolyzed casein compared to native casein formula (77.4 ± 17 and 51.2 ± 20%), but there was no difference after naloxone pretreatment (77.1 ± 16 and 76.5 ± 17%). Discussion: The present data suggest that hydrolysis of casein accelerates GIT via reduction of opioid activity released during digestion. Further studies are required to investigate to which extent these rat pub data apply to preterm infants.

© 2005 S. Karger AG, Basel


  

Author Contacts

Dr. Walter A. Mihatsch
Universitätsklinik und Poliklinik für Kinder- und Jugendmedizin
DE–89075 Ulm (Germany)
Tel. +49 731 5002 7740, Fax +49 731 5002 6723
E-Mail walter.mihatsch@medizin.uni-ulm.de

  

Article Information

Received: March 11, 2004
Accepted after revision: September 20, 2004
Published online: November 29, 2004
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 24

  

Publication Details

Biology of the Neonate (Fetal and Neonatal Research)

Vol. 87, No. 3, Year 2005 (Cover Date: Released April 2005)

Journal Editor: Halliday, H.L. (Belfast)
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/bon


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2004
Accepted: 9/20/2004
Published online: 4/6/2005
Issue release date: April 2005

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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